Evidence map›Paper›PMID 42357647›Full record

ReviewViruses2026

Exploring the Isoprenoid Biosynthesis Pathway's Role in Oncogenic Viruses.

Louise N Blaha, Jeffrey D Neighbors, Richa Sandeep, Akhila Kondaka, Raymond J Hohl

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Louise N BlahaPenn State Cancer Institute, Hershey, PA 17033, USA.
Jeffrey D NeighborsPenn State Cancer Institute, Hershey, PA 17033, USA.
Richa SandeepDepartment of Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.
Akhila KondakaDepartment of Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.
Raymond J HohlPenn State Cancer Institute, Hershey, PA 17033, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncogenic viruses, which are causative for some cancers, are typically acquired in youth and suppressed until older age. These malignancies account for over 10% of the cancer burden and often reprogram cellular metabolic pathways to promote their own survival and proliferation, often targeting lipogenic pathways to increase bioavailability of cellular products. The isoprenoid biosynthesis pathway (IBP) is an important lipogenic pathway that has been explored extensively for its dysregulation contributing to carcinogenesis, with notable discussion of statin therapy as a means of perturbing neoplasia. To our knowledge, we are the first group to provide a comprehensive discussion of the seven known oncogenic viruses and their reliance upon the IBP to promote tumorigenesis. As knowledge on this topic is limited, we aim to draw attention to a neglected area of the oncogenic research space, while also highlighting the use of inhibitors of the IBP as potential avenues for novel treatment options.

Indexed as

Oncogenic VirusesTerpenesAnimalsCarcinogenesisCholesterolHumansMetabolic Networks and PathwaysMevalonic AcidNeoplasmsPolyisoprenyl PhosphatesSesquiterpenesCholesterolfarnesyl pyrophosphategeranylgeranyl pyrophosphateMevalonic AcidPolyisoprenyl PhosphatesSesquiterpenesTerpenescholesterolfarnesyl pyrophosphategeranylgeranyl pyrophosphateHMGCRisoprenoidsmevalonatemicroRNAoncovirusprenylationstatin

Identifiers

PMID42357647
PMCPMC13307802

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.