Evidence map›Paper›PMID 42357613›Full record

ArticleViruses2026

Type I Interferon Regulation of HLA-F Expression in Human Trophoblasts During Viral Infection.

Diana Manchorova, Jiahui Ding, Annie Thy Nguyen, Tanya Dimova, Sergey Slavov, Liubomir Djerov, Ruqun Zheng, Gil Mor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Diana ManchorovaC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Jiahui DingC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0001-7747-2071
Annie Thy NguyenC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-9178-5813
Tanya DimovaInstitute of Biology and Immunology of Reproduction "Acad. Kiril Bratanov", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-8665-4352
Sergey SlavovObstetrics and Gynecology Department, Medical University, University Obstetrics and Gynecology Hospital "Maichin Dom", 1431 Sofia, Bulgaria.ORCID 0000-0002-7438-0144
Liubomir DjerovObstetrics and Gynecology Department, Medical University, University Obstetrics and Gynecology Hospital "Maichin Dom", 1431 Sofia, Bulgaria.
Ruqun ZhengDepartment of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong 999077, China.
Gil MorC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-5499-3912

Funding

Research Experience & Training Coordination CoreP42ES030991 · NIEHS · WAYNE STATE UNIVERSITY · PI Glen Ray Hood · 2022 to 2026
$13.9M
Sex-dimorphic Placental Adaptation to Benzene Exposure: Implications for Fetal and Postnatal Immunological DevelopmentU54ES038382 · NIEHS · WAYNE STATE UNIVERSITY · PI Jayanth Ramadoss · 2026 to 2026
$3.0M
Impact of benzene-induced MIA on fetal T cell developmentR01HD111146 · NICHD · WAYNE STATE UNIVERSITY · PI MOR, GIL G · 2023 to 2025
$1.1M
National Institute of Allergy and Infectious Diseases R01AI145829National National Institute of Child Health and Human Development R01HD111146NICHD NIH HHS R01 HD111146NIEHS NIH HHS P42 ES030991NIEHS NIH HHS P42ES030991NIEHS NIH HHS U54 ES038382
6 · The paper itself

Abstract

The role of human leukocyte antigen F (HLA-F) at the maternal-fetal interface (MFI) during viral infection and its regulation by interferon signaling remains poorly understood. Here, we investigated HLA-F expression and regulation in first-trimester trophoblast cells following activation of the type I interferon pathway and viral infection. We demonstrate that HLA-F is significantly upregulated at both mRNA and protein levels in response to Poly(I:C) and IFN-β in a dose- and time-dependent manner, suggesting its regulation as an interferon-stimulated gene (ISG). Zika virus (ZIKV) infection similarly induced HLA-F upregulation over time. In contrast, HSV-2 infection downregulated HLA-F mRNA while maintaining steady protein levels, indicative of virus-specific regulatory mechanisms. Moreover, we identified a soluble form of HLA-F secreted following Poly(I:C) stimulation. These findings reveal that HLA-F is dynamically regulated in trophoblasts during viral challenge and type I IFN signaling activation, supporting its broader immunomodulatory role in antiviral defense and immune tolerance at the MFI.

Indexed as

Gene Expression RegulationHistocompatibility Antigens Class IInterferon Type ITrophoblastsVirus DiseasesFemaleHerpesvirus 2, HumanHumansPoly I-CPregnancyPregnancy Trimester, FirstSignal TransductionZika VirusHistocompatibility Antigens Class IHLA-F antigensInterferon Type IPoly I-Chuman leukocyte antigen Fmaternal–fetal interfacetype I interferon pathwayZika virus

Identifiers

PMID42357613
PMCPMC13307695

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.