Evidence map›Paper›PMID 42357448›Full record

ArticleMolecules (Basel, Switzerland)2026

Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation.

Shuli Li, Yulin He, Hiotong Kam, Hanbin Chen, Jin-Song Bian, Nan Xu, Guiyi Gong, Qiwen Liao, Chen Zhao, Binrui Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shuli LiState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.ORCID 0009-0003-6567-8605
Yulin HeDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.
Hiotong KamDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.ORCID 0000-0001-8241-2874
Hanbin ChenJoint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0003-2271-7769
Jin-Song BianJoint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.
Nan XuState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.
Guiyi GongDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.ORCID 0000-0002-6495-0545
Qiwen LiaoDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.
Chen ZhaoDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China.
Binrui YangNutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China.
Liang ChenNutrilite Health Institute, Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China.ORCID 0000-0001-7434-4461
Kit Ieng KuokCrystal Vision Biotechnology Limited, Taipa, Macao 999078, China.
Simon Ming Yuen LeeState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.ORCID 0000-0002-3966-6569

Funding

Hong Kong Polytechnic University A0051173National Natural Science Foundation of China 82505059Science and Technology Development Fund 0008/2023/AMR
6 · The paper itself

Abstract

Neuroinflammation, mediated by microglia and astrocytes, is an abnormal immune reaction in central nervous system (CNS) disorders. Stimulation of TRPV1 has been found to enhance microglial activation, resulting in a pro-inflammatory response. Natural anthraquinones such as physcion and rhein are commonly found in rhubarb, a medicinal plant recognized for its dual role in culinary and therapeutic applications. The therapeutic potential and mechanisms of these anthraquinones remain largely unexplored. This research aims to examine how anthraquinones protect against neuroinflammation and delineate the underlying mechanisms in lipopolysaccharide (LPS)-mediated cellular and zebrafish models. Among the representative anthraquinone analogs, physcion and rhein showed potent functional inhibitory activity against the TRPV1 channel. The production of nitric oxide (NO) and secretion of pro-inflammatory factors triggered by LPS were significantly reduced in BV-2 cells through regulation of

Indexed as

AnthraquinonesEmodinLipopolysaccharidesNeuroinflammatory DiseasesRheumTRPV Cation ChannelsAnimalsAnti-Inflammatory AgentsCalciumCell LineMiceMicrogliaNitric OxideSignal TransductionZebrafishAnthraquinonesAnti-Inflammatory AgentsCalciumEmodinLipopolysaccharidesNitric OxidephyscionerheinTRPV Cation ChannelsanthraquinonesneuroinflammationphyscionrheinrhubarbTRPV1

Identifiers

PMID42357448
PMCPMC13304890

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.