Evidence map›Paper›PMID 42357338›Full record

ReviewPharmaceutics2026

Toxin-Derived Peptides as Potentials Weapons Against Cancer.

Bárbara Pinto, Joaquim Teixeira de Avelar Júnior, Edleusa Marques Lima, Lívia Ramos Santiago, Rosy Iara Maciel de Azambuja Ribeiro, Renata Toscano Simões, Cristina Moraes Junta, Rachel Carolina Souza Fagundes, Ana Clara Costa Velozo, Hassan Bousbaa and 4 more

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bárbara PintoDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-8804-6104
Joaquim Teixeira de Avelar JúniorPrograma de Pós-Graduação em Inovação Tecnológica, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-8265-6342
Edleusa Marques LimaNúcleo de Ensino Pesquisa e Inovação-NEPI, Pesquisa Clínica Instituto Mário Penna, Rua Gentios, 1420, Terceiro Pavimento, Conjunto Santa Maria, Belo Horizonte 30380-472, Brazil.
Lívia Ramos SantiagoLaboratório de Patologia Experimental, Universidade Federal de São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Bairro Chanadour, Divinópolis 35501-296, Brazil.ORCID 0000-0002-9288-2519
Rosy Iara Maciel de Azambuja RibeiroLaboratório de Patologia Experimental, Universidade Federal de São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Bairro Chanadour, Divinópolis 35501-296, Brazil.ORCID 0000-0002-7374-4743
Renata Toscano SimõesPrograma de Pós-Graduação em Medicina-Biomedicina, Faculdade de Saúde Santa Casa de Belo Horizonte (PPG/FSCBH), Av. dos Andradas, 2688 Bairro Santa Efigênia, Belo Horizonte 30110-005, Brazil.ORCID 0000-0003-3569-0788
Cristina Moraes JuntaPrograma de Pós-Graduação em Medicina-Biomedicina, Faculdade de Saúde Santa Casa de Belo Horizonte (PPG/FSCBH), Av. dos Andradas, 2688 Bairro Santa Efigênia, Belo Horizonte 30110-005, Brazil.
Rachel Carolina Souza FagundesDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.
Ana Clara Costa VelozoPrograma de Pós-Graduação em Medicina-Biomedicina, Faculdade de Saúde Santa Casa de Belo Horizonte (PPG/FSCBH), Av. dos Andradas, 2688 Bairro Santa Efigênia, Belo Horizonte 30110-005, Brazil.ORCID 0000-0003-3143-0866
Hassan BousbaaUNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal.ORCID 0000-0002-4006-5779
Miriam Teresa Paz LopesLaboratório de Substâncias Antitumorais, Departamento Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.
Juliana Carvalho-TavaresDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.
Elaine Maria de Souza-FagundesDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.
Maria Elena de LimaPrograma de Pós-Graduação em Inovação Tecnológica, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-6185-4032

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 310638/2023-2Conselho Nacional de Desenvolvimento Científico e Tecnológico 406048/2018-5[ES1.1]Cooperativa de Ensino Superior Politécnico e Universitário BD/CBAS/CESPU/01/2020Foundation for Science and Technology 2022.09451.BDFundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00428-21Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ 00754-24Fundação de Amparo à Pesquisa do Estado de Minas Gerais BPD-00174Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00185-23-PEPBI/OFundação de Amparo à Pesquisa do Estado de São Paulo 2025/01407-4;JPFundação de Amparo à Pesquisa do Estado de São Paulo 2026/01556-2Fundação de Amparo à Pesquisa do Estado de São Paulo AT-BIOTA
6 · The paper itself

Abstract

Cancer, a longstanding global challenge, remains a leading cause of death, prompting an urgent search for effective treatments. Conventional therapies, while prevalent, often cause adverse effects due to their lack of specificity. This review explores an innovative approach, focusing on animal toxins as a rich source of bioactive compounds which have demonstrated efficacy against cancer cells. Peptides from various species, including scorpions, snakes, bees, spiders, and frogs, show promising antiproliferative and cytotoxic effects. Emphasizing the most prevalent types of cancer, this review outlines the discovery and development stages of potential anticancer drugs derived from toxin peptides. The comprehensive overview includes in vitro and in vivo assessments of their anticancer activity and toxicity. This pioneering exploration extends to different tumors, offering valuable insights into mechanisms of action and potential therapeutic applications. The findings highlight a paradigm shift in cancer research, showcasing the potential of toxin-derived compounds for developing targeted and efficient cancer therapies with reduced side effects.

Indexed as

animal toxinsanticancer activityantimicrobial peptides (AMPs)drug delivery systemsmechanism of actiontherapeutic applications of peptidestoxin peptides

Identifiers

PMID42357338
PMCPMC13306627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.