Evidence map›Paper›PMID 42357280›Full record

ArticlePharmaceutics2026

Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Predicted Enhanced Affinity for the Parasite Target cTXNPx.

Arielly R R Barreto, Ana Paula C Valente, Edgar Schaeffer, Vitor M de Almeida, Michelle F Muzitano, Thiago Barth, Alessandra M T de Souza, Bárbara de A A Vieira, Alcides Monteiro da Silva, Osvaldo A Santos-Filho and 2 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arielly R R BarretoInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Ana Paula C ValenteInstituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-7219-1123
Edgar SchaefferInstituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Vitor M de AlmeidaInstituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-7902-6876
Michelle F MuzitanoFaculdade de Farmácia, Campus Macaé, Universidade Federal do Rio de Janeiro, Macaé 27930-560, RJ, Brazil.ORCID 0000-0003-0155-3240
Thiago BarthFaculdade de Farmácia, Campus Macaé, Universidade Federal do Rio de Janeiro, Macaé 27930-560, RJ, Brazil.
Alessandra M T de SouzaFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-9986-405X
Bárbara de A A VieiraFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Alcides Monteiro da SilvaInstituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0002-3200-0318
Osvaldo A Santos-FilhoInstituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-7407-158X
Patrick G SteelDepartment of Chemistry, Durham University, Durham DH1 3LE, UK.ORCID 0000-0002-2493-5826
Bartira Rossi-BergmannInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0002-3791-8996

Funding

FAPERJ E-26/010.000982/2019National Council for Scientific and Technological Development 315438/2021-5The Royal Society IC160044
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chalconecTXNPxCYPleishmaniasisliver microsomes

Identifiers

PMID42357280
PMCPMC13306700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.