ArticlePolymers2026
Molecularly Imprinted Membranes: From Protein Recognition to Refolding Activity.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Molecular imprinting is a powerful strategy for fabricating synthetic materials with selective recognition toward specific biomolecules. In this work, molecularly imprinted (MIM) membranes based on poly (ethylene-co-vinyl alcohol) (EVAL) were developed for selective protein recognition and conformational modulation using α-amylase as a model template. Membranes were prepared by phase inversion, generating porous structures suitable for mass transport and adsorption. Template extraction, measured using UV-Vis spectroscopy, showed a rapid and effective removal of α-amylase while preserving membrane morphology, as confirmed by SEM. FTIR-ATR and chemical imaging confirmed template removal from the membrane and a uniform surface distribution of rebound α-amylase after successive template incubation. Rebinding experiments showed a concentration-dependent uptake of α-amylase and an apparent saturation trend at higher concentrations. Selectivity tests using bovine serum albumin as an analog confirmed preferential recognition of α-amylase. Enzymatic assays showed partial recovery of catalytic activity after rebinding of thermally denatured α-amylase, indicating that imprinted cavities may promote protein conformational reorganization. These results highlight the potential of EVAL-based imprinted membranes as biomimetic platforms for selective protein recognition and functional modulation.
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