Evidence map›Paper›PMID 42356950›Full record

ArticlePolymers2026

Phase-Inversion In Situ Implants for Dental Drug Delivery: A QbD-Guided In Vitro Technological Evaluation.

Elena O Bakhrushina, Polina S Sakharova, Mariya V Kotilevskaya, Iosif B Mikhel, Galina E Brkich, Natalya V Pyatigorskaya, Anzhela S Brago, Grigory Yu Evzikov, Yuriy L Vasiliev

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In one paragraph

Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elena O BakhrushinaDepartment of Pharmaceutical Technology, A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.ORCID 0000-0001-8695-0346
Polina S SakharovaDepartment of Pharmaceutical Technology, A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.
Mariya V KotilevskayaDepartment of Pharmaceutical Technology, A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.
Iosif B MikhelDepartment of Pharmaceutical Technology, A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.ORCID 0000-0002-2866-0049
Galina E BrkichDepartment of Industrial Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.
Natalya V PyatigorskayaDepartment of Industrial Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.
Anzhela S BragoDepartment of Propaedeutics of Dental Diseases, Institute of Medicine, Peoples' Friendship University of Russia Named After Patrice Lumumba, Moscow 117198, Russia.ORCID 0000-0001-8947-4357
Grigory Yu EvzikovDepartment of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.
Yuriy L VasilievDepartment of Operative Surgery and Topographic Anatomy, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phase-inversion in situ implants (PIISIs) represent a versatile polymer platform in which the rational choice of matrix former and solvent system directly governs the macroscopic properties of the resulting depot. This study applied a Quality by Design (QbD) approach to rationalize a bleached shellac-based PIISI, with particular focus on the physicochemical interactions between the polymer and the injection vehicle. Bleached shellac-a natural, low-cost, biodegradable oligomeric resin bearing -COOH, -OH, and ester functional groups-was selected as the matrix former and screened in seven neat solvents and five 1:1 binary combinations at 25% (m/m). Twelve formulations were evaluated against a predefined set of critical quality attributes, including injectability, phase-inversion kinetics, solvent diffusion volume, and implant structure (n = 5 per formulation; mean ± standard deviation (SD); one-way analysis of variance (ANOVA) with Tukey's post hoc test,

Indexed as

critical quality attributesperiodontal drug deliveryphase-inversion in situ implantquality by designshellacsolvent screening

Identifiers

PMID42356950
PMCPMC13306396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.