Evidence map›Paper›PMID 42356500›Full record

ReviewPharmaceuticals (Basel, Switzerland)2026

The Methanesulfonamide Group: Bright and Dark Sides of hERG Potassium Channel Inhibition.

Zsigmond Máté Kovács, József Óvári, János Magyar, Tamás Bányász, Péter P Nánási, Balázs Horváth, Gábor Balogh, Norbert Szentandrássy

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zsigmond Máté KovácsDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0009-0003-7669-8695
József ÓváriDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
János MagyarDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0001-7999-2505
Tamás BányászDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-3894-0738
Péter P NánásiDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Balázs HorváthDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-2562-8446
Gábor BaloghDivision of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0009-0008-1487-5584
Norbert SzentandrássyDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-0197-9567

Funding

National Research, Development and Innovation Office 142764National Research, Development and Innovation Office 147301
6 · The paper itself

Abstract

Our review focuses on methanesulfonamide-containing compounds, a well-characterized class of high-affinity blockers of the hERG potassium channel, which plays a critical role in cardiac repolarization by mediating the cardiac I

Indexed as

action potentialsclass III antiarrhythmicshERG channelIKrmethanesulfonamide

Identifiers

PMID42356500
PMCPMC13305193

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.