Combined Aerobic and Resistance Training Improves Metabolic Health and Is Associated with Arginine and Histidine Metabolic Changes During the Transition from Metabolically Unhealthy to Metabolically Healthy Obesity in Young Adults.

Xueyin Fei, Min Wu, Yanchun Li, Mengru Zhang, Xiangang Yang

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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Resistance Training with Aerobic Active Recovery in Obesity and Metabolic Syndrome: Translational Rationale, Proposed Training Protocol, and Multi-Omics Research Framework-A Narrative Review.Journal of clinical medicine · 2026
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5 · Who and what money

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5 authors.

Xueyin FeiDepartment of Exercise Biochemistry, Sport Science School, Beijing Sport University, Beijing 100084, China.ORCID 0009-0009-5666-5144

Min WuDepartment of Physical Education, China Agricultural University, Beijing 100083, China.

Yanchun LiChina Institute of Sports and Health Science, Beijing Sport University, Beijing 100084, China.ORCID 0000-0003-0892-2264

Mengru ZhangDepartment of Heavy Athletics Teaching and Research Section, School of Competitive Sports, Beijing Sport University, Beijing 100084, China.

Xiangang YangChina Shooting College, Hebei Provincial Sports Bureau, Shijiazhuang 050041, China.

Funding

Hebei Sport University Sports Health Integration Technology Innovation Platform Construction Research Project 285748

6 · The paper itself

Abstract

backgroundExercise training is known to improve metabolic health in individuals with obesity; however, its role in facilitating transitions between metabolically unhealthy obesity (MUO) and metabolically healthy obesity (MHO), as well as the associated metabolic adaptations, remains incompletely understood.

methodsA total of 84 young adults with obesity were enrolled and classified MUO (

resultsExercise training improved cardiometabolic risk profiles, including reductions in adiposity and improvements in insulin resistance-related markers. A proportion of participants transitioned from metabolically unhealthy to metabolically healthy obesity following the intervention. No significant between-group differences in amino acid metabolite changes were observed between MHO-R and MUO-C groups. Exploratory metabolomic analyses identified exercise-responsive alterations in amino acid-related metabolites, particularly involving arginine biosynthesis and histidine metabolism.

conclusionsCombined aerobic and resistance training is associated with improvements in metabolic health and phenotype transition in young adults with obesity. Observed alterations in arginine and histidine metabolism may reflect metabolic adaptations to exercise rather than transition-specific or causal mechanisms underlying phenotype conversion.

Indexed as

ArginineExerciseHistidineObesityObesity, Metabolically BenignResistance TrainingAdultBody CompositionFemaleHumansInsulin ResistanceMaleMetabolomicsYoung AdultArginineHistidineamino acid metabolismexercise traininginsulin resistancemetabolically unhealthy obesitymetabolic phenotype transition

Identifiers

PMID42356343

DOI10.3390/nu18121956

PMCPMC13305316

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