Evidence map›Paper›PMID 42356278›Full record

ArticleNutrients2026

Bioactive Low-Molecular-Weight Fraction from

Luckman Gbati, María Jesús Rodríguez-Sojo, Jose Alberto Molina-Tijeras, Jorge García-García, Laura López-Escánez, Teresa Vezza, Antonio Jesús Ruiz-Malagon, Djeri Bouraïma, Federico García, Julio Gálvez and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Luckman GbatiDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.ORCID 0009-0009-9301-632X
María Jesús Rodríguez-SojoDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.
Jose Alberto Molina-TijerasDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.ORCID 0000-0003-1554-9226
Jorge García-GarcíaInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain.ORCID 0000-0003-0925-9441
Laura López-EscánezDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.
Teresa VezzaInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain.ORCID 0000-0002-9780-0180
Antonio Jesús Ruiz-MalagonDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.ORCID 0000-0003-4323-650X
Djeri BouraïmaMicrobiology and Food Quality Control Laboratory (LAMICODA), Higher School of Biological and Food Techniques (ESTBA), University of Lomé, Lomé 01 BP 1515, Togo.
Federico GarcíaInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain.ORCID 0000-0001-7611-781X
Julio GálvezDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.ORCID 0000-0001-6876-3782
Alba Rodríguez-NogalesDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.ORCID 0000-0003-1927-0628
María Elena Rodríguez-CabezasDepartment of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.ORCID 0000-0001-9085-8147

Funding

Institute of Health Carlos III CD23/00234Institute of Health Carlos III FI20/00159Institute of Health Carlos III IFI21/00030Institute of Health Carlos III PI19/01058Institute of Health Carlos III PI20/01447Institute of Health Carlos III PI22/0163Junta de Andalucía B-CTS-664-UGR20Junta de Andalucía CTS164Junta de Andalucía P18-RT-4930Junta de Andalucía PY20-01157
6 · The paper itself

Abstract

backgroundPostbiotics, including cell-free supernatants and their fractions, have emerged as a safe and effective alternative to live probiotics for managing intestinal inflammation. This study investigated the protective effects of low-molecular-weight fractions (<3 kDa) of the probiotic

methodsMale C57BL/6J mice were orally administered LMW-LF for 10 days prior to colitis induction with 3% dextran sodium sulfate (DSS) for 5 days. Colonic damage was assessed via the Disease Activity Index (DAI), histology, and immunofluorescence (Ocln and Ki67). Immune cell populations were analyzed by flow cytometry, while mucosal gene expression and gut microbiota composition were evaluated using RT-qPCR and 16S rRNA sequencing, respectively.

resultsLMW-LF administration significantly attenuated clinical symptoms and macroscopic colonic damage. Treatment restored epithelial barrier integrity by upregulating tight junction proteins (

conclusionsLMW-LF is an active fraction acting across the host-microbiota axis. By integrating epithelial protection, immunomodulation, and microbial reshaping, it represents a promising dietary strategy for the management of Inflammatory Bowel Diseases.

Indexed as

ColitisDysbiosisLimosilactobacillus fermentumProbioticsAnimalsColonCytokinesDextran SulfateDisease Models, AnimalGastrointestinal MicrobiomeInflammationIntestinal Barrier FunctionIntestinal MucosaMaleMiceMice, Inbred C57BLCytokinesDextran SulfateTjp1 protein, mouseZonula Occludens-1 ProteinDSS-induced colitisgut microbiotaimmunomodulationintestinal barrierLimosilactobacillus fermentum CECT5716postbiotics

Identifiers

PMID42356278
PMCPMC13305965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.