Evidence map›Paper›PMID 42355510›Full record

ArticleLife (Basel, Switzerland)2026

Intracellular Calcium Overload Promotes NFATc1-ATF3 Activation and Induces the Senescence-Associated Phenotype in Irradiated Osteocytes.

Haiqing Han, Fanyu Zhao, Jianping Wang, Jianglong Zhai, Guoying Zhu

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haiqing HanInstitute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Fanyu ZhaoInstitute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Jianping WangInstitute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Jianglong ZhaiInstitute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.
Guoying ZhuInstitute of Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, China.ORCID 0000-0001-5637-5184

Funding

Shanghai Municipal Health Commission GWVI-11.1-40
6 · The paper itself

Abstract

Although calcium overload dysregulation has been implicated in cellular senescence, its role in ionizing radiation (IR)-induced osteocyte senescence, a key pathogenic mechanism underlying radiotherapy-associated bone injury, remains poorly explored. This study investigated whether IR-induced osteocyte senescence is mediated through the Ca

Indexed as

ATF3bone homeostasiscalcium overloadionizing radiationNFATc1osteocyte senescence

Identifiers

PMID42355510
PMCPMC13301319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.