ArticleLife (Basel, Switzerland)2026
Hyposalivation Treatment with Non-Crosslinked Hyaluronic Acid and Amino Acids Solution-A Clinical Pilot Study.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309588 (Hyposalivation Treatment With Non-crosslinked Hyaluronic Acid and Amino Acids Solution), which is not on this map. Not yet cited in PubMed.
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Hyposalivation Treatment With Non-crosslinked Hyaluronic Acid and Amino Acids Solution
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3 authors.
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Abstract
backgroundThis randomized controlled clinical study aimed to evaluate changes in salivary secretion following injections of a hyaluronic acid and amino acid solution in patients with hyposalivation. MATERIALS AND
methodsA total of 100 patients with symptoms of hyposalivation were randomly assigned to either a study group or a control group (1:1). The consistency and pH of unstimulated saliva, as well as the volume and buffering capacity of stimulated saliva, were assessed using the Saliva-Check Buffer GC test at baseline and after the study period. Patients in the study group received injections of a hyaluronic acid and amino acid solution into the buccal mucosa in four sessions at two-week intervals, while the control group received no intervention.
resultsSignificant improvements were observed in the intervention group, including favorable changes in the consistency and pH of unstimulated saliva as well as increases in the volume and buffering capacity of stimulated saliva over the study period. A paired
conclusionsInjections of a hyaluronic acid and amino acid solution may represent a promising therapeutic option for patients with symptoms of dry mouth. Study registered on Clinicaltrials NCT07309588.
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