Fecal Microbiota Transplantation Improves Biota and Hepatic Metabolism, Promoting Growth in SD Rats Under Hypobaric Hypoxia Exposure.

Shuting Bao, Shengchun Xu, Zhilong Wang, Shatuo Chai, Shuxiang Wang, Dongwen Dai, Xun Wang, Jiaying Lv

Abstract read

In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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5 · Who and what money

Authors and funding

8 authors.

Shuting BaoAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.

Shengchun XuAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.

Zhilong WangAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.

Shatuo ChaiAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.

Shuxiang WangAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.

Dongwen DaiAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.

Xun WangAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.

Jiaying LvAcademy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China.ORCID 0000-0001-8606-9698

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypobaric hypoxia poses a serious threat to growth and development and can induce pronounced inflammatory responses. These effects are closely associated with the gut microbiota. However, the underlying mechanisms, particularly the role of gut microbiota in regulating hepatic metabolism under chronic hypoxic conditions, remain poorly understood. In this study, SD rats were used as recipients and assigned to three groups: a hypobaric hypoxia group (H), an antibiotic-treated group (HA), and an antibiotic-treated group receiving fecal microbiota transplantation from plateau zokors (HAM). All rats were maintained in a hypobaric hypoxia chamber simulating an altitude of 6000 m for 30 days. Subsequently, growth performance, routine hematological parameters, and multi-omics profiles were evaluated. Compared with the H group, both the HAM and HA groups showed significantly increased average daily gain (ADG) (

Indexed as

growthgut microbiotahypobaric hypoxiainflammationlivermetabolome

Identifiers

PMID42354994

DOI10.3390/microorganisms14061370

PMCPMC13305931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.