Evidence map›Paper›PMID 42354940›Full record

ReviewMicroorganisms2026

Targeting Zoonotic Spillover Drivers for Global Pandemic Prevention: A Narrative Review.

Alexandra Mpakosi, Vasileios Cholevas, Alexandra Lianou, Foteini Tziraki, Ioannis Vogiatzis, Stamatios Cholevas, Ioannis Tzouvelekis, Maria Mironidou-Tzouveleki, Konstantina A Tsante, Deny Tsakri and 5 more

Abstract readReview
In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexandra MpakosiDepartment of Immunology, General Hospital of Nikaia "Agios Panteleimon", 18454 Piraeus, Greece.ORCID 0000-0002-9833-8477
Vasileios CholevasSchool of Medicine, University of Bologna, 40126 Bologna, Italy.
Alexandra LianouNeonatal Intensive Care Unit, General Hospital of Nikaia "Agios Panteleimon", 18454 Piraeus, Greece.ORCID 0000-0002-8588-8672
Foteini TzirakiDepartment of Immunology, General Hospital of Nikaia "Agios Panteleimon", 18454 Piraeus, Greece.ORCID 0009-0005-6168-3217
Ioannis VogiatzisDepartment of Immunology, General Hospital of Nikaia "Agios Panteleimon", 18454 Piraeus, Greece.
Stamatios CholevasSchool of Pharmacy, European University of Cyprus, Diogenes 2404, Engomi, 2404 Nicosia, Cyprus.
Ioannis TzouvelekisSchool of Agricultural Technology, Food Technology and Nutrition, Alexander Technological Educational Institute of Thessaloniki, 57400 Thessaloniki, Greece.
Maria Mironidou-TzouvelekiDepartment of Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Konstantina A TsanteLaboratory of Haematology and Blood Bank Unit, "Attikon" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Deny TsakriDepartment of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0009-0003-1978-5864
Vasileios Petrakis2nd University Department of Internal Medicine, Department of Infectious Diseases, University General Hospital Alexandroupolis, Democritus University Thrace, 691 00 Komotini, Greece.ORCID 0000-0002-9065-4811
Petros IoannouSchool of Medicine, University of Crete, 710 03 Heraklion, Greece.ORCID 0000-0003-1082-5674
Stefanos BonovasDepartment of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Milan, Italy.ORCID 0000-0001-6102-6579
Rozeta SokouNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0002-9972-8901
Andreas G TsantesLaboratory of Haematology and Blood Bank Unit, "Attikon" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-3695-0759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zoonoses account for the majority of recognized mammalian viral spillover events, primarily originating from bats, rodents, and primates. Human activities have significantly accelerated these transmissions. This narrative review synthesizes the evolutionary, ecological, pathogen-related, and anthropogenic drivers of viral zoonotic spillover to identify critical leverage points for pandemic prevention. A narrative literature review was conducted. The analysis focused on factors enabling animal pathogens to transform into human pathogens, examining host species, pathogen traits, human-animal interactions, and environmental impacts. Pathogen transformation depends on host traits, contact frequency, and viral characteristics. Anthropogenic drivers-including livestock expansion, the bushmeat trade, wet markets, and the exotic pet industry-significantly elevate spillover risks. Effective pandemic prevention requires targeted interventions at the wildlife-livestock-human interfaces. A holistic, multidisciplinary collaboration between national governments and international organizations is essential to mitigate future risks.

Indexed as

influenza viruspandemicSARS-CoV-2spillover eventviral infectionzoonoses

Identifiers

PMID42354940
PMCPMC13303194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.