Oleanolic Acid Modulates the Gut-Liver Axis to Alleviate High-Fat Diet-Induced Hepatic Lipid Deposition in Nile Tilapia (

Kai Yu, Xuhong Yang, Ruijie Guo, Kai Huang, Jiagang Deng

Abstract read

In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kai YuGuangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning 530200, China.ORCID 0000-0001-5338-3437

Xuhong YangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Ruijie GuoCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Kai HuangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Jiagang DengGuangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning 530200, China.

Funding

Guangxi Science and Technology Department 2025GXNSFBA069220Guangxi Science and Technology Department Guike AA23026008National Natural Science Foundation of China 32160865

6 · The paper itself

Abstract

This study examined the protective mechanisms of oleanolic acid (OA) against high-fat diet (HFD)-induced hepatic steatosis and intestinal dysbiosis in Nile tilapia. Fish were allocated to four groups: normal diet (ND), HFD, and OA-supplemented HFD (50 and 250 mg/kg). After 42 days, physiological, biochemical, and histological assessments demonstrated that OA markedly reduced hepatic lipid accumulation, mitochondrial injury, and intestinal shortening. Transcriptomic analysis revealed that OA alleviated lipid dysregulation by inhibiting de novo lipogenesis and promoting lipid trafficking and β-oxidation, effectively reversing HFD-induced changes in the PPAR, MAPK, mTOR, and autophagy-lysosome signaling pathways. 16S rRNA sequencing indicated that OA increased microbial alpha diversity, suppressing HFD-associated taxa (e.g.,

Indexed as

gut–liver axisgut microbiotahigh-fat dietnon-alcoholic fatty liver diseaseoleanolic acidOreochromis niloticusshort-chain fatty acids

Identifiers

PMID42354872

DOI10.3390/microorganisms14061247

PMCPMC13303720

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