Evidence map›Paper›PMID 42354819›Full record

ArticleMicroorganisms2026

Differences in RNA Binding Between Segmented and Non-Segmented Negative-Strand Virus Nucleocapsids.

Rob W H Ruigrok, Allison Ballandras-Colas, Thibaut Crépin, Hélène Malet, Dan Kolakofsky

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rob W H RuigrokUniversity Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France.
Allison Ballandras-ColasUniversity Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France.
Thibaut CrépinUniversity Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France.ORCID 0000-0003-2663-1794
Hélène MaletUniversity Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France.
Dan KolakofskyDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, Medical School, University of Geneva, 1211 Geneva, Switzerland.

Funding

Agence Nationale de la Recherche ANR-21-CE15-0026
6 · The paper itself

Abstract

Segmented and non-segmented negative-strand RNA viruses share the same general pathway for genome transcription, which generates messenger RNA, and genome replication which duplicates the viral RNA. These processes are performed by the viral polymerase and necessitate the viral RNA to be coated by a non-covalent polymer of nucleoproteins known as nucleocapsid. The non-segmented negative-strand RNA viruses (nsNSVs) have rigid nucleocapsids covering the entire tightly bound genome and require a phosphoprotein cofactor for proper replication and transcription by the polymerase, while the segmented negative-strand RNA viruses (sNSVs) have very flexible nucleocapsids with only few nucleotides tightly bound to each nucleoprotein, and their viral RNA genome ends are directly bound to the polymerase. We discuss here how the differences in RNA binding are likely to be crucial for proper replication and transcription in both nsNSVs and sNSVs.

Indexed as

negative-strand RNA virusnucleocapsidRNA

Identifiers

PMID42354819
PMCPMC13303740

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.