Evidence map›Paper›PMID 42354715›Full record

ArticleMicromachines2026

Mechanics of Long-Shank 5 mm Neural Probe Insertion into the Rat Brain: Effects of Geometry and Vibration-Assisted Insertion.

Mahasty Khajehzadeh, Christopher K Nguyen, Mrigank Maharana, Shriya Peddapuram, Alexandra Joshi-Imre, Juan M Pascual, Stuart F Cogan

Abstract read
In one paragraph

Article in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahasty KhajehzadehDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0009-0007-2850-0436
Christopher K NguyenDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0002-6596-4869
Mrigank MaharanaDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0009-0008-6791-1729
Shriya PeddapuramDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.
Alexandra Joshi-ImreOffice of Research and Innovation, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0002-4271-1623
Juan M PascualDivision of Child Neurology, Department of Pediatrics, Neurology, Neuroscience and Philosophy, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-0843-8221
Stuart F CoganDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0001-6316-3032

Funding

Brain Glucose Deficiency: Mechanisms and ModulationRM1NS133593 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joseph J. Pancrazio, Juan M. Pascual · 2023 to 2026
$5.3M
Mechanisms of Motor SuperperformanceR01NS133439 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Juan M. Pascual · 2024 to 2026
$1.7M
NIH HHS 1R01NS104344-04NIH HHS 1RM1NS133593-02NINDS NIH HHS R01 NS133439NINDS NIH HHS RM1 NS133593
6 · The paper itself

Abstract

Insertion of microelectrode arrays (MEAs) into brain tissue remains a mechanical challenge, especially for long, thin probes designed to access deep structures. This study investigates the mechanical properties of 5 mm long amorphous silicon carbide (a-SiC) probes with different geometries and the effect of vibration-assisted insertion on penetration into rat brain.

methodsTwo planar a-SiC probe designs were fabricated with identical lengths and thicknesses but differing width geometries: one with a uniform width (175 µm) and the other with a tapered shape (tapering from 175 to 75 µm). Critical buckling forces (FCs) were estimated by finite element modeling (FEM) and validated experimentally. Insertion mechanics were assessed in a brain mimic of 1.2% agarose gel at varying insertion speeds (20-1000 µm/s) and in vivo by implantation in rat cortex. Insertion metrics included penetration force (F

resultsThe tapered design exhibited lower penetration force and higher insertion success compared to the uniform-width probe, despite having a lower critical buckling force. An optimal insertion rate of 100 µm/s was identified, balancing insertion time with low F

conclusionsA tapered probe geometry and vibration-assisted insertion can reduce F

Indexed as

amorphous silicon carbide (a-SiC)cortical implantationdimpling depthinsertion forceintracortical microelectrode array (MEA)neural interfaces

Identifiers

PMID42354715
PMCPMC13303758

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.