Ice Templated PEG-Alginate Double-Network Cryogels with Tunable Mechanics and Degradation for Soft Tissue Engineering.

Kaixiang Zhang, Michael Patrick Seitz, Matthew Pinto, William Ofori-Atta Eghan, Era Jain

Abstract read

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Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Kaixiang ZhangDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.

Michael Patrick SeitzDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.

Matthew PintoDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.

William Ofori-Atta EghanDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.

Era JainDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.ORCID 0000-0002-7172-401X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scaffolds designed for mechanically demanding soft tissue engineering applications should integrate mechanical support, efficient mass transfer, and good cellular compatibility. This work presents a one-pot method based on "radical-free click chemistry + carbodiimide coupling" to produce a double-network (DN) PEG-alginate cryogel. The PEG network is formed by a Michael addition reaction between thiol-based crosslinker and 8-arm PEG-acrylate. The second network is covalently crosslinked through EDC/NHS-mediated coupling of carboxyl groups in alginate and adipic acid dihydrazide (AAD). The subsequent freezing and gelation of the gel precursor at sub-zero temperatures results in an ice templated cryogel with an interconnected macroporous network. These cryogels demonstrate high elasticity, compressive modulus and rapid swelling equilibrium in aqueous environments, as well as controlled degradation under physiological conditions. Compared to the classical Ca

Indexed as

cartilage tissue engineeringcryogelsdouble networkhydrogelsmacroporous scaffoldsstem cell-macrophage crosstalk

Identifiers

PMID42354430

DOI10.3390/gels12060533

PMCPMC13299618

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.