ArticleGels (Basel, Switzerland)2026
Chlorogenic Acid-Embedded Hydrogel for Visual pH Monitoring and Enhanced Antibacterial Performance.
Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Bacteria-infected wounds remain a major global biomedical challenge, with persistent inflammation and the lack of real-time monitoring significantly impairing wound healing. To address the limitations of conventional dressings, which often provide single-function and static treatment, we developed a multifunctional HP@CGA hydrogel based on methacrylated hyaluronic acid (HA-MA) and polyvinyl alcohol (PVA), incorporating chlorogenic acid (CGA) and bromothymol blue (BTB). In the presence of a photoinitiator, the methacryloyl groups of HA-MA undergo UV-induced free-radical polymerization to form a covalently crosslinked network, while PVA chains interact with the HA-MA backbone through hydrogen bonding and physical entanglement, resulting in a stable interpenetrating double-network structure. This integrated "treatment + monitoring" design offers a low-cost and convenient alternative to conventional wound dressings and separate sensing systems. Material characterization and preliminary experiments demonstrated that the hydrogel enabled visual pH detection within the range of 6.0-8.0 through distinct color changes. In addition, it exhibited excellent antibacterial activity, achieving antibacterial rates of 99.9% ± 0.08% against both
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