Microencapsulated OPO Enhances Intestinal SCFA Production by Optimizing Lipid Digestion and Regulating Bile Acid Metabolism in Mice.

Haocheng Liu, Chao Pang, Shiyu Luo, Zhandong Yang, Jiguo Yang

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haocheng LiuSchool of Public Health and Health Management, Gannan Medical University, Ganzhou 341000, China.

Chao PangSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.

Shiyu LuoSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.

Zhandong YangGuangzhou National Laboratory, Guangzhou 510005, China.ORCID 0009-0003-9540-8964

Jiguo YangSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.

Funding

National Key Research and Development Program of China 2022YFF1100103

6 · The paper itself

Abstract

1,3-Dioleoyl-2-palmitoylglycerol (OPO) mimics breast milk fat, yet its regulation of gut short-chain fatty acids (SCFAs) remains unclear. Herein, stable OPO microcapsules (94.12% efficiency) were prepared using soy protein isolate/maltodextrin. Integrating metabolomics and transcriptomics in mice, we found OPO intervention dose-dependently increased acetic, propanoic, and butyric acids in the jejunum and colon. Multi-omics analysis revealed OPO upregulated key genes governing lipid digestion (FABP2, NPC1L1, MTTP) and bile secretion (ABCA1). These results indicate that OPO is closely associated with increased SCFA production, suggesting a potential pathway wherein optimized host nutrient digestion and absorption patterns create a favorable metabolic environment for distal microbial fermentation, rather than merely providing substrates. This study provides correlative multi-omics insights into a potential mechanism for OPO's health benefits in functional foods.

Indexed as

intestinal digestionmetabolomicsmicroencapsulationOPO structural lipidsshort-chain fatty acidstranscriptomics

Identifiers

PMID42354047

DOI10.3390/foods15122075

PMCPMC13298450

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.