ArticleChildren (Basel, Switzerland)2026
Longitudinal Trends of Salivary Oxidized Thymosin β4 and β10 in Preterm Infants with Bronchopulmonary Dysplasia.
Chiara Tirone, Simona Fattore, Nicoletta Menzella, Davide De Tomaso, Martina Giaimo, Stefano Cecere, Alessandro Perri, Irene Messana, Tiziana Cabras, Barbara Manconi and 7 more
Abstract read
In one paragraphArticle in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
17 authors.
Chiara TironeNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0001-9191-4219 Simona FattoreNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-2991-2068 Nicoletta MenzellaNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0009-0009-8023-167X Davide De TomasoNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Martina GiaimoNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Stefano CecereNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Alessandro PerriNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-8914-8639 Irene MessanaIstituto di Scienze e Tecnologie Chimiche "Giulio Natta", Consiglio Nazionale delle Ricerche, 20132 Milan, Italy.
Tiziana CabrasDipartimento di Scienze della Vita e dell'Ambiente, Sezione Biomedica, Università di Cagliari, 09042 Monserrato, Italy.ORCID 0000-0001-7535-9825 Barbara ManconiDipartimento di Scienze della Vita e dell'Ambiente, Sezione Biomedica, Università di Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-2880-9915 Alessandra OlianasDipartimento di Scienze della Vita e dell'Ambiente, Sezione Biomedica, Università di Cagliari, 09042 Monserrato, Italy.ORCID 0000-0003-4238-3233 Cristina ContiniDipartimento di Scienze della Vita e dell'Ambiente, Sezione Biomedica, Università di Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-0903-4675 Giulia GuadalupiDipartimento di Scienze della Vita e dell'Ambiente, Sezione Biomedica, Università di Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-0448-276X Gavino FaaDipartimento di Scienze Mediche e Sanità Pubblica, Università di Cagliari, 09042 Monserrato, Italy.
Massimo CastagnolaLaboratorio di Proteomica, Centro Europeo di Ricerca sul Cervello, Fondazione Santa Lucia IRCCS, 00179 Rome, Italy.ORCID 0000-0002-0959-7259 Federica IavaroneClinical Chemistry, Biochemistry and Molecular Biology Operations (UOC), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-2074-5531 Giovanni VentoNeonatology Unit, Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-3121-9569 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundOxidative stress plays a key role in the pathogenesis of complications in preterm infants, including bronchopulmonary dysplasia (BPD). Thymosin β4 (Tβ4) and thymosin β10 (Tβ10) are proteins involved in tissue repair and responses to oxidative stress, but their role in extremely preterm neonates remains poorly understood.
methodsA total of 149 saliva samples from 18 infants with gestational age < 30 weeks were analyzed. Salivary proteins and their proteoforms were characterized using an integrated proteomic platform based on nano-HPLC-ESI-MS. Relative quantification was performed using extracted ion current (XIC) peak areas. Associations with postmenstrual age, oxygen requirement, and BPD development were assessed, including longitudinal analysis using generalized estimating equation (GEE) models.
resultsSignificant correlations were found between postmenstrual age and total Tβ4 (
conclusionsAlthough no early differences were detected, longitudinal trajectories of Tβ4 and Tβ10 differed between infants with and without BPD. Postnatal changes in these proteins may be associated with differences in clinical course and exposure to postnatal oxidative stress.
Indexed as
bronchopulmonary dysplasiaoxidized Tβ10oxidized Tβ4preterm newbornsproteomicssaliva proteomethymosin
Identifiers
PMID42353940
PMCPMC13296937
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LicenceCC BY
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