ArticleGenes2026
THBS1 as a Key Regulator of Myoblasts: Validation of Its Inhibitory Roles in Skeletal Muscle Development.
Ji Qi, Xinlin Jin, Jing Wang, Yunzhou Wang, Wei Chen, Hongzhen Cao, Jingsen Huang, Hui Tang, Junfeng Chen, Baosong Xing and 1 more
Abstract read
In one paragraphArticle in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Ji QiShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.ORCID 0009-0005-3838-100X Xinlin JinShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Jing WangHenan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Henan Pig Breeding Engineering Research Centre, Institute of Animal Husbandry, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
Yunzhou WangDepartment of Veterinary Medicine, Shandong Vocational Animal Science and Veterinary College, Weifang 261061, China.
Wei ChenShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.ORCID 0000-0002-2901-5156 Hongzhen CaoShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.ORCID 0009-0005-3906-9181 Jingsen HuangShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.ORCID 0009-0002-2874-2164 Hui TangShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.
Junfeng ChenHenan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Henan Pig Breeding Engineering Research Centre, Institute of Animal Husbandry, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
Baosong XingHenan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Henan Pig Breeding Engineering Research Centre, Institute of Animal Husbandry, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
Yongqing ZengShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.ORCID 0000-0002-0740-2470 Funding
National Natural Science Foundation of China 2021YFD1301200Shandong Province Animal Husbandry and Veterinary Bureau 2020LZGC012Shandong Province Animal Husbandry and Veterinary Bureau SDAIT-08-02
6 · The paper itselfAbstract
backgroundThromboxane B2 Synthase 1 (THBS1), also known as TSP-1, is a multifunctional glycoprotein involved in various cellular processes that plays a crucial role in skeletal muscle development and repair. It acts as a key physiological activator of transforming growth factor-β1 (TGF-β1), both in vivo and in vitro.
methodsThis study aimed to investigate the effects of THBS1 on myoblast proliferation and differentiation using the mouse skeletal muscle satellite cell line C2C12 and to reveal its regulatory relationship with the TGF-β signaling pathway through a series of cellular and molecular experiments.
resultsOverexpression or knockout of
conclusionsThese results provide a theoretical foundation for future research aimed at enhancing skeletal muscle quality in livestock and poultry and lay the groundwork for developing therapeutic strategies for skeletal muscle disorders.
Indexed as
Muscle DevelopmentMuscle, SkeletalMyoblastsThrombospondin 1AnimalsCell DifferentiationCell LineCell ProliferationMiceSignal TransductionTransforming Growth Factor beta1Thbs1 protein, mouseThrombospondin 1Transforming Growth Factor beta1cellular differentiationmyoblastsskeletal muscleTGF-β signaling pathwayTHBS1
Identifiers
PMID42353879
PMCPMC13300539
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