Evidence map›Paper›PMID 42353760›Full record

ReviewGenes2026

Genetic Testing in Gastrointestinal Polyposis Syndromes: Considerations in Pediatrics.

Suzanne P MacFarland, Kristin Zelley, Isabel Rojas, Carol Durno

Abstract readReview
In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Suzanne P MacFarlandDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Kristin ZelleyDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Isabel RojasUniversity of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Carol DurnoHospital for Sick Children, Toronto, ON M5G 1E8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric gastrointestinal polyps are frequently associated with an underlying hereditary syndrome associated with multisystem manifestations and increased risk of early-onset cancer. Thus, the identification of polyps in a child should prompt evaluation with genetic testing to (1) characterize the syndrome to determine next clinical steps including surveillance recommendations, and (2) conduct cascade testing to identify affected family members. Given the considerations for pediatric genetic testing, including autonomy and psychosocial stressors associated with the early detection of a cancer risk syndrome, it is important to conduct targeted testing. Herein, we propose a stepwise approach to genetic testing in the pediatric patient with gastrointestinal polyps.

Indexed as

Adenomatous Polyposis ColiGenetic TestingIntestinal PolyposisPeutz-Jeghers SyndromeChildHumansNeoplastic Syndromes, Hereditaryfamilial adenomatous polyposisjuvenile polyposis syndromePeutz-Jeghers syndromepolyposis syndromesPTEN hamartoma tumor syndrome

Identifiers

PMID42353760
PMCPMC13298831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.