Role of Mobilome in Carbapenem Resistance.

Laiba Hassan, Muhammad Ali Syed, Binghuai Lu, Jiankang Zhao, Bin Cao

Abstract readReview

In one paragraph

Review in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laiba HassanDepartment of Microbiology, The University of Haripur, Haripur 22620, Pakistan.

Muhammad Ali SyedDepartment of Microbiology, The University of Haripur, Haripur 22620, Pakistan.ORCID 0000-0002-1576-3508

Binghuai LuNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, New Cornerstone Science Laboratory, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.

Jiankang ZhaoNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, New Cornerstone Science Laboratory, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.ORCID 0000-0002-2758-2034

Bin CaoNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, New Cornerstone Science Laboratory, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.

Funding

Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences CIFMS2021-12M-1-048Elite Medical Professionals Project of China-Japan Friendship Hospital ZRJY2023-QM32National Natural Science Foundation of China (NSFC) 82102456National Natural Science Foundation of China (NSFC) 82530002

6 · The paper itself

Abstract

Growing resistance to carbapenem antibiotics is a major public health problem as these antibiotics are considered the last line of therapy for infections caused by multidrug-resistant (MDR) Gram-negative bacteria. The rapid emergence and dissemination of carbapenem-resistant bacterial strains are mainly due to horizontal gene transfer (HGT) within or between bacterial cells via the mobilome. The aim of this article is to discuss the role of mobile genetic elements (MGEs) that capture and disseminate resistance determinants of carbapenem antibiotics, as a comprehensive review integrating the combined role of plasmids, transposons and integrons. It attempts to systematically fill the gap by investigating the role of these MGEs in the acquisition, mobilization and dissemination of genes encoding carbapenemases across clinically important bacteria. Various types of plasmids such as IncF and IncH in

Indexed as

carbapenemintegronsmobilomeplasmidstransposons

Identifiers

PMID42353666

DOI10.3390/antibiotics15060542

PMCPMC13295470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.