Evidence map›Paper›PMID 42353655›Full record

ArticleAntibiotics (Basel, Switzerland)2026

Effectiveness and Safety of First-Line Empirical Eradication Therapy with Rebamipide: Results from the European Registry on

Dmitry S Bordin, Dmitrii N Andreev, Sayar R Abdulkhakov, Irina N Voynovan, Igor G Bakulin, Natalia V Bakulina, Ludmila G Vologzhanina, Boris D Starostin, Aiman S Sarsenbayeva, Tatyana A Ilchishina and 39 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Dmitry S BordinDepartment of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia.ORCID 0000-0003-2815-3992
Dmitrii N AndreevDepartment of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia.ORCID 0000-0002-4007-7112
Sayar R AbdulkhakovDepartment of Internal Diseases, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0001-9542-3580
Irina N VoynovanDepartment of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia.ORCID 0000-0002-5584-8514
Igor G BakulinDepartment of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University, 191015 Saint Petersburg, Russia.
Natalia V BakulinaDepartment of Internal Medicine, Clinical Pharmacology and Nephrology, I.I. Mechnikov North-Western State Medical University, 191015 Saint Petersburg, Russia.
Ludmila G VologzhaninaDepartment of Faculty Therapy No. 1, Perm State Medical University named after Academician E.A. Wagner, 614990 Perm, Russia.
Boris D StarostinInterdistrict Gastroenterological Center No. 1, City Polyclinic No. 38, 191015 Saint Petersburg, Russia.ORCID 0009-0000-3286-1882
Aiman S SarsenbayevaDepartment of Therapy, Institute of Additional Professional Education, South Ural State Medical University, 454092 Chelyabinsk, Russia.
Tatyana A IlchishinaMedical Holding "SM-Clinic" (Medi Com LLC), 194355 Saint Petersburg, Russia.ORCID 0000-0002-2327-5248
Larisa V TarasovaDepartment of Hospital Therapy, I.N. Ulyanov Chuvash State University, 428015 Cheboksary, Russia.
Alla G KononovaDepartment of Outpatient Therapy and Family Medicine, Tver State Medical University, 170100 Tver, Russia.
Sergey A AlekseenkoDepartment of Hospital Therapy, Far Eastern State Medical University, 680000 Khabarovsk, Russia.
Oleg V ZaytsevFirst Clinical Medical Centre, 601900 Kovrov, Russia.
Natalya N DekhnichDepartment of Faculty Therapy, Smolensk State Medical University, 214019 Smolensk, Russia.
Pavel O BogomolovDepartment of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia.
Galina N TarasovaDepartment of Internal Diseases Propaedeutics, Rostov State Medical University, 344022 Rostov-on-Don, Russia.
Olga A KolokolnikovaDepartment of Gastroenterology and Genetically Engineered Biological Therapy, MEDSI Clinical Hospital No. 1 in Otradnoye, 143442 Moscow Region, Russia.
Igor B KhlynovDepartment of Faculty Therapy and Geriatrics, Ural State Medical University, 620028 Yekaterinburg, Russia.
Ekaterina Yu PlotnikovaDepartment of Outpatient Therapy, Postgraduate Education and Nursing Care, Kemerovo State Medical University, 650029 Kemerovo, Russia.
Natalia V BaryshnikovaDepartment of Internal Diseases, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.ORCID 0000-0001-7429-0336
Maria A LivzanDepartment of Faculty Therapy and Gastroenterology, Omsk State Medical University, 644099 Omsk, Russia.ORCID 0000-0002-6581-7017
Marina F OsipenkoDepartment of Propaedeutics of Internal Diseases, Novosibirsk State Medical University, 630091 Novosibirsk, Russia.
Natalya V BakanovaGastroenterology Service, Medical Center "Medicea", 426000 Izhevsk, Russia.
Ekaterina V Partsvania-VinogradovaDepartment of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia.
Margarita V ChebotarevaDepartment of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia.
Rustam A AbdulkhakovDepartment of Hospital Therapy, Faculty of Medicine, Kazan State Medical University, 420012 Kazan, Russia.
Inna V SavilovaDepartment of Internal Medicine, Clinical Pharmacology and Nephrology, I.I. Mechnikov North-Western State Medical University, 191015 Saint Petersburg, Russia.
Anastasia G SushilovaDepartment of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University, 191015 Saint Petersburg, Russia.
Sergey V KolbasnikovDepartment of Outpatient Therapy and Family Medicine, Tver State Medical University, 170100 Tver, Russia.
Alsu R KhurmatullinaDepartment of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia.ORCID 0009-0000-4358-7823
Igor V MaevDepartment of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia.
Maria O TishchenkoInterdistrict Gastroenterological Center No. 1, City Polyclinic No. 38, 191015 Saint Petersburg, Russia.
Rimma E PetrovaInterdistrict Gastroenterological Center No. 1, City Polyclinic No. 38, 191015 Saint Petersburg, Russia.
Ludmila V MorkovkinaDepartment of Hospital Therapy, I.N. Ulyanov Chuvash State University, 428015 Cheboksary, Russia.
Yulia V TsyganovaDepartment of Hospital Therapy, I.N. Ulyanov Chuvash State University, 428015 Cheboksary, Russia.
Margarita D KozlovaDepartment of Faculty Therapy, Smolensk State Medical University, 214019 Smolensk, Russia.
Aleksei A IakovlevDepartment of Internal Diseases Propaedeutics, Rostov State Medical University, 344022 Rostov-on-Don, Russia.
Alexander S VolkovDepartment of Internal Diseases Propaedeutics, Rostov State Medical University, 344022 Rostov-on-Don, Russia.
Elizaveta S MorozDepartment of Gastroenterology and Genetically Engineered Biological Therapy, MEDSI Clinical Hospital No. 1 in Otradnoye, 143442 Moscow Region, Russia.
Olga V GausDepartment of Faculty Therapy and Gastroenterology, Omsk State Medical University, 644099 Omsk, Russia.ORCID 0000-0001-9370-4768
Singla AlbaGastrointestinal Oncology, Endoscopy and Surgery (GOES) Research Group, Althaia Xarxa Assistencial Universitària de Manresa, Institut de Recerca i Innovació en Ciències de la Vida i de la Salut a la Catalunya Central (IRIS-CC), 08243 Manresa, Spain.
Oriol FarrésGastrointestinal Oncology, Endoscopy and Surgery (GOES) Research Group, Althaia Xarxa Assistencial Universitària de Manresa, Institut de Recerca i Innovació en Ciències de la Vida i de la Salut a la Catalunya Central (IRIS-CC), 08243 Manresa, Spain.
Leticia MoreiraGastroenterology Service, Institute of Digestive and Metabolic Diseases (ICMDM), Hospital Clínic de Barcelona, CIBEREHD, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-4518-8591
Pablo ParraDepartment of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.ORCID 0009-0002-8597-2206
Olga P NyssenDepartment of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.ORCID 0000-0002-4920-9310
Francis MegraudINSERM U1312 BRIC, University of Bordeaux, 33076 Bordeaux, France.
Colm O'MorainSchool of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.ORCID 0000-0002-1847-6782
Javier P GisbertDepartment of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.

Funding

European Union programme HORIZON 101095359UK Research and Innovation 10058099
6 · The paper itself

Abstract

BACKGROUND/

objectiveEradication of

methodsTreatment-naïve patient data were collected between January 2020 and August 2024 from the European Registry on Helicobacter pylori Management (Hp-EuReg), an international, prospective, multicentre, observational study. Rebamipide-containing regimens were analysed and compared with those without rebamipide. Effectiveness was assessed using a modified intention-to-treat approach.

resultsOverall, 4581 patients (mean age 48 ± 15 years, 64% women) from 15 Russian cities were included. From those, 820 patients received eradication therapy with rebamipide and 3761 without rebamipide. Overall effectiveness was significantly higher with rebamipide (731/763, 96%) than without it (2785/3059, 91%) (

conclusionsIn this observational registry cohort, first-line empirical triple therapy with amoxicillin-clarithromycin, and quadruple therapy with amoxicillin-clarithromycin-bismuth, both prescribed with rebamipide, were associated with higher eradication rates than regimens without rebamipide.

Indexed as

antimicrobial therapyeradicationHelicobacter pylorirebamipideregistrytreatment

Identifiers

PMID42353655
PMCPMC13296271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.