ArticleCurrent issues in molecular biology2026
Inflammatory Cytokine Genetics and Coronary Artery Disease: Pathogenetic and Protective Analysis of IL-18 (-607 C/A, -137 G/C) and IL-8 (+781 C/T) Gene Variations.
Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic inflammation mediated by cytokines is central to the pathogenesis of coronary artery disease (CAD). This exploratory study aimed to investigate potential associations between functional gene variations of the cytokines interleukin 18 (IL-18) and interleukin 8 (IL-8) and the CAD susceptibility within a specific regional cohort, while accounting for common clinical comorbidities. Genotype distributions of IL-18 (-607 C/A, -137 G/C) and IL-8 (+781 C/T) were analyzed in a cohort of 102 patients with angiographically confirmed CAD and 102 healthy controls. Genotyping was performed using PCR, allele-specific PCR, and RFLP techniques. Multivariate logistic regression was utilized to assess potential independent associations, adjusting for age and traditional clinical risk factors. In this specific cohort, after adjusting for age, hypertension, diabetes, cholesterol, family history, and smoking, the IL-18 (-137 G/C) CC genotype was observed more frequently in CAD patients (adjusted odds ratio [AOR] = 6.15, 95% CI = 2.10-18.05,
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