Evidence map›Paper›PMID 42353575›Full record

ArticleCurrent issues in molecular biology2026

Salbutamol and Formoterol Attenuate Okadaic Acid-Induced Cytotoxicity in Undifferentiated PC-12 Cells: Evidence for a β2-Adrenergic Receptor-Independent Protective Component.

Andria Kotsoni, Evelina Ioannou, Evangelia Barmparousi, Lefteris C Zacharia

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andria KotsoniDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Ave, CY-2417 Nicosia, Cyprus.
Evelina IoannouDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Ave, CY-2417 Nicosia, Cyprus.
Evangelia BarmparousiDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Ave, CY-2417 Nicosia, Cyprus.
Lefteris C ZachariaDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Ave, CY-2417 Nicosia, Cyprus.ORCID 0000-0002-0327-2373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β2-adrenergic receptor (β2-AR) agonists have been implicated in neuroprotection, yet their mechanisms remain obscure. We examined whether salbutamol (SA, short-acting) or formoterol (FO, long-acting) protect PC-12 cells from okadaic acid (OA), and evaluated receptor dependence, antioxidant capacity, and apoptotic signaling. Viability was quantified with crystal violet and MTT assays. OA reduced viability to approximately 60%, and SA or FO (0.1-10 µM) improved survival, which reached 76-83% at 10 µM (

Indexed as

formoterolokadaic acidokadaic acid-induced cytotoxicityPC-12 cellssalbutamolβ2-adrenergic receptors

Identifiers

PMID42353575
PMCPMC13298259

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.