Comparative Effects of Copper Glycinate and Potassium Diformate on Immunity and Gut Microbiota of Pigs-Potential Analysis of Potassium Diformate as a Copper Additive Substitute.

Xueyuan Jiang, Hulong Lei, Yuan Mei, Peng Jia, Wen Yao, Dong Xia, Naisheng Lu

Abstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xueyuan JiangKey Laboratory of Livestock and Poultry Resources (Pig) Evaluation and Utilization of Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.ORCID 0000-0003-4333-3801

Hulong LeiKey Laboratory of Livestock and Poultry Resources (Pig) Evaluation and Utilization of Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.

Yuan MeiKey Laboratory of Livestock and Poultry Resources (Pig) Evaluation and Utilization of Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.

Peng JiaKey Laboratory of Livestock and Poultry Resources (Pig) Evaluation and Utilization of Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.

Wen YaoCollege of Animal Science &Technology, Nanjing Agricultural University, Nanjing 210095, China.

Dong XiaKey Laboratory of Livestock and Poultry Resources (Pig) Evaluation and Utilization of Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.

Naisheng LuKey Laboratory of Livestock and Poultry Resources (Pig) Evaluation and Utilization of Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.ORCID 0000-0003-0849-1572

Funding

National Natural Science Foundation of China 32100033Shanghai Agriculture Applied Technology Development Program G20190301

6 · The paper itself

Abstract

Copper supplements are prominent antibiotic alternatives in livestock production, but their excessive use poses environmental risks, necessitating safer substitutes. Potassium diformate (KDF), an organic acid salt, has shown potential as a feed additive, yet its effectiveness in copper-unsupplemented diets remains unclear. This study compared the effects of copper glycinate (Cu_Gly) and KDF on weaned piglets fed a copper-unsupplemented basal diet. Forty-five Meishan piglets were allocated to a control group (basal diet), a Cu_Gly group (basal diet + 60 mg/kg Cu_Gly), or a KDF group (basal diet + 10 g/kg KDF). The KDF group exhibited a lower feed conversion ratio (FCR) than the control group. Although no significant differences in average daily gain were observed, KDF supplementation significantly enhanced immune function by increasing plasma IgG and decreasing IgM, IL-6, and IL-1 levels compared to the control. 16S rRNA sequencing analysis revealed that the Control group was enriched with pathogenic genera (

Indexed as

copperdietfeed additiveimmunitymicrobiotapotassium diformate

Identifiers

PMID42353498

DOI10.3390/ani16121889

PMCPMC13296155

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.