Defining the Impact of Genetics on Equine Performance and Development of Orthopaedic Disease.

Hannah Chernavsky, Lynn M Pezzanite, Steve Simske, Chris E Kawcak

Abstract readReview

In one paragraph

Review in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hannah ChernavskyOrthopaedic Research Center, Translational Medicine Institute, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0009-0001-2598-6780

Lynn M PezzaniteOrthopaedic Research Center, Translational Medicine Institute, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-4990-5006

Steve SimskeWalter Scott, Jr. College of Engineering, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-6937-1956

Chris E KawcakOrthopaedic Research Center, Translational Medicine Institute, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-2401-9710

Funding

Equine Orthopaedic Research Center n/a

6 · The paper itself

Abstract

In equine veterinary medicine, there is a lack of correlation between the structural severity of orthopaedic disease and the perceived severity of presenting signs, resulting in a variable influence on performance, pain and disability. Across equine industries, there is selective pressure through breeding for specific traits, such as the "speed" gene (MSTN) in racing thoroughbreds and the "gait keeper" gene (DMTR3) in pacing breeds, potentially resulting in genetic predispositions that lead to an increased risk of musculoskeletal disorders. With advancements in molecular sequencing techniques, researchers have been able to identify various genes (e.g., ECA, RUNX, and ADAME1) as well as biomarkers influencing performance and the development of orthopaedic disease. In combination, these techniques could be applied clinically in the future to improve welfare and disease management through advanced characterization and treatments to delay the onset of orthopaedic disease.

Indexed as

equinegeneticsorthopaedic diseaseperformance

Identifiers

PMID42353485

DOI10.3390/ani16121875

PMCPMC13295833

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.