ArticleInternational journal of molecular sciences2026
High-Level Secretory Expression of Recombinant Type XVII Human-like Collagen in
Yixuan Jia, Junhao Yue, Wanting Wu, Weirui Zhao, Sheng Hu, Lehe Mei, Peilian Wei, Changjiang Lyu
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Yixuan JiaSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Junhao YueSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Wanting WuSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Weirui ZhaoSchool of Biological and Chemical Engineering, Ningbo Tech University, Ningbo 315100, China.
Sheng HuSchool of Biological and Chemical Engineering, Ningbo Tech University, Ningbo 315100, China.ORCID 0009-0008-6467-4262 Lehe MeiSchool of Biological and Chemical Engineering, Ningbo Tech University, Ningbo 315100, China.
Peilian WeiSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Changjiang LyuSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Funding
Ministry of Natural Resources HY202305National Natural Science Foundation of China 32371542Tianjin Institute of Industrial Biotechnology (No. 2021KF003)Zhejiang Provincial Natural Science Foundation LY23B060001
6 · The paper itselfAbstract
Type XVII collagen (COL17) is crucial for skin integrity but difficult to produce. To achieve high-level secretory expression, a human COL17 segment was designed and cloned into the pPIC9K vector with six different α-mating factor signal peptides and integrated into
Indexed as
AutoantigensNon-Fibrillar CollagensSaccharomycetalesCell ProliferationCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIICollagen Type XVIIFibroblastsFilaggrin ProteinsHumansKeratinocytesMatrix Metalloproteinase 3Reactive Oxygen SpeciesRecombinant ProteinsUltraviolet RaysAutoantigensCOL3A1 protein, humanCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIICollagen Type XVIIFilaggrin ProteinsFLG protein, humanMatrix Metalloproteinase 3Non-Fibrillar CollagensReactive Oxygen SpeciesRecombinant Proteinshuman foreskin fibroblastsimmortalized keratinocytesKomagataella phaffiisecretory expressiontype XVII collagen
Identifiers
PMID42353332
PMCPMC13299338
What OpenQuestion holds
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