Evidence map›Paper›PMID 42353315›Full record

ArticleInternational journal of molecular sciences2026

Super-Resolution 3D Imaging Reveals Disarray of Dyadic Calcium Ion Channels in Failing Hearts Expressing Low Thyroid Hormone Function.

Atieh Ashkezari, Megha Schmalzle, Amanda Charest, Sanketh Kumar, Riddhi Modi, Nicholas Nasta, Andrea Bertolini, Alessandro Saba, Paolo Cifani, Youhua Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Atieh AshkezariDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.
Megha SchmalzleDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.ORCID 0009-0002-7599-9501
Amanda CharestDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.
Sanketh KumarDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.
Riddhi ModiDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.
Nicholas NastaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.
Andrea BertoliniDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.ORCID 0000-0003-4810-7061
Alessandro SabaDepartment of Pathology, University of Pisa, Via Savi, 10, 56126 Pisa, Italy.ORCID 0000-0003-0611-5549
Paolo CifaniMass Spectrometry Shared Resource, Cold Spring Harbor Laboratory, 1 Bungtown Rd., Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-4403-1277
Youhua ZhangDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.ORCID 0000-0002-9003-2705
A Martin GerdesDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.
Randy F StoutDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.
Kaie OjamaaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, 600 Northern Blvd, Old Westbury, NY 11568, USA.

Funding

Cold Spring Harbor Laboratory 5P30CA045508NIH HHS 1R15HL154068-01
6 · The paper itself

Abstract

Ventricular remodeling occurring in heart failure (HF) involves structural disarray of the sarcolemma T-tubule (TT)-sarcoplasmic reticulum (SR) dyad junctions, thereby disrupting the close apposition of L-type Ca

Indexed as

Calcium Channels, L-TypeHeart FailureImaging, Three-DimensionalRyanodine Receptor Calcium Release ChannelThyroid HormonesAnimalsCalciumMaleMembrane ProteinsMyocytes, CardiacRatsSarcoplasmic ReticulumCalciumCalcium Channels, L-TypejunctophilinMembrane ProteinsRyanodine Receptor Calcium Release ChannelThyroid Hormones3D STORMjunctophilin-2L-type calcium channelryanodine receptor-2thyroid hormone (T3)

Identifiers

PMID42353315
PMCPMC13299204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.