The Involvement of the Small GTPase Rac1 in Insulin Signaling That Regulates Plasma Membrane Translocation of the Fatty Acid Transporter CD36 in Mouse White Adipocytes.

Nobuyuki Takenaka, Mizuki Sakata, Yuki Abe, Kokoa Iha, Takaya Satoh

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Nobuyuki TakenakaLaboratory of Cell Biology, Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Sakai 599-8531, Osaka, Japan.

Mizuki SakataLaboratory of Cell Biology, Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Sakai 599-8531, Osaka, Japan.

Yuki AbeLaboratory of Cell Biology, Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Sakai 599-8531, Osaka, Japan.

Kokoa IhaLaboratory of Cell Biology, Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Sakai 599-8531, Osaka, Japan.

Takaya SatohLaboratory of Cell Biology, Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Sakai 599-8531, Osaka, Japan.ORCID 0000-0001-9543-700X

Funding

Ministry of Education, Culture, Sports, Science and Technology 19K06665, 20K06559, and 25K09616Naito Foundation No Grant Number

6 · The paper itself

Abstract

A fraction of the insulin-stimulated uptake of long-chain fatty acids (FAs) is mediated by the FA translocase cluster of differentiation 36 (CD36) in white adipocytes. Intracellular vesicle-localized CD36 is redistributed to the plasma membrane following insulin stimulation, enhancing the uptake of long-chain FAs across the plasma membrane. We previously developed an epitope-tagged CD36 reporter, which enabled the visualization and quantification of the plasma membrane translocation of CD36. Herein, we demonstrate that the insulin-stimulated CD36 translocation is regulated by the phosphoinositide 3-kinase (PI3K)/Akt2/Rac1/RalA axis in adipocytes of subcutaneous white adipose tissue (WAT) in living mice. The uptake of long-chain FAs by insulin was completely abrogated in white adipocytes isolated from adipocyte-specific

Indexed as

Adipocytes, WhiteCD36 AntigensCell MembraneInsulinNeuropeptidesrac1 GTP-Binding ProteinSignal TransductionAnimalsFatty AcidsMiceMice, KnockoutPhosphatidylinositol 3-KinasesProtein TransportProto-Oncogene Proteins c-aktral GTP-Binding ProteinsAkt2 protein, mouseCD36 AntigensCd36 protein, mouseFatty AcidsInsulinNeuropeptidesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktrac1 GTP-Binding ProteinRac1 protein, mouseRala protein, mouseral GTP-Binding ProteinsAkt2cluster of differentiation 36GTPaseinsulinlong-chain fatty acidsRac1RalAwhite adipocyte

Identifiers

PMID42353282

DOI10.3390/ijms27125568

PMCPMC13300478

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.