Evidence map›Paper›PMID 42353273›Full record

ArticleInternational journal of molecular sciences2026

Cross-Presentation and Activation of CD8+ T Cells: The Role of Pannexin-1 in Dendritic Cells.

Francisco Bravo, Paulina Troncoso, Javier Mena, Catalina Bascuñan, Nayiberg Varas, Daniela Sauma, Claudio Acuña-Castillo, Carlos Barrera-Avalos

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francisco BravoCentro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.ORCID 0009-0003-8451-8754
Paulina TroncosoDepartamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 9160000, Chile.
Javier MenaCentro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.ORCID 0000-0001-5758-0470
Catalina BascuñanDepartamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 9160000, Chile.
Nayiberg VarasCentro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.ORCID 0009-0002-7651-5089
Daniela SaumaDepartamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 9160000, Chile.ORCID 0000-0001-8622-3245
Claudio Acuña-CastilloCentro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.ORCID 0000-0003-3607-6077
Carlos Barrera-AvalosCentro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.ORCID 0000-0001-6160-9563

Funding

Agencia Nacional de Investigación y Desarrollo 11231081Agencia Nacional de Investigación y Desarrollo 1231554
6 · The paper itself

Abstract

Cross-presentation of exogenous antigens by dendritic cells (DCs) relies on the cytosolic pathway, enabling proteasomal processing and subsequent loading of antigenic peptides onto major histocompatibility complex class I (MHC-I) molecules. Although this pathway is central to CD8

Indexed as

Antigen PresentationCD8-Positive T-LymphocytesConnexinsCross-PrimingDendritic CellsLymphocyte ActivationNerve Tissue ProteinsAnimalsMiceMice, Inbred C57BLOvalbuminConnexinsNerve Tissue ProteinsOvalbuminPanx1 protein, mousecross-presentationcytosolic pathwaydendritic cellsPannexin-1

Identifiers

PMID42353273
PMCPMC13299963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.