Evidence map›Paper›PMID 42353193›Full record

ArticleInternational journal of molecular sciences2026

20(S/R)-Ginsenoside Rh1 Alleviates AOM/DSS-Induced Colorectal Cancer: Gut-Microbiota Modulation and Tryptophan-Metabolism-Mediated AhR/PXR Activation and IDO1.

Linqian Lu, Jinyu Min, Yansong Gao, Ge Yang, Zijian Zhao, You Kang, Yujuan Zhao, Lei Zhao, Shengyu Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linqian LuSchool of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China.
Jinyu MinSchool of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China.
Yansong GaoInstitute of Agro-Food Technology, Jilin Academy of Agricultural Sciences (Northeast Agricultural Research Center of China), Changchun 130033, China.
Ge YangInstitute of Agro-Food Technology, Jilin Academy of Agricultural Sciences (Northeast Agricultural Research Center of China), Changchun 130033, China.
Zijian ZhaoInstitute of Agro-Food Technology, Jilin Academy of Agricultural Sciences (Northeast Agricultural Research Center of China), Changchun 130033, China.ORCID 0000-0002-6140-3423
You KangInstitute of Agro-Food Technology, Jilin Academy of Agricultural Sciences (Northeast Agricultural Research Center of China), Changchun 130033, China.
Yujuan ZhaoInstitute of Agro-Food Technology, Jilin Academy of Agricultural Sciences (Northeast Agricultural Research Center of China), Changchun 130033, China.
Lei ZhaoSchool of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China.ORCID 0000-0001-5831-617X
Shengyu LiInstitute of Agro-Food Technology, Jilin Academy of Agricultural Sciences (Northeast Agricultural Research Center of China), Changchun 130033, China.ORCID 0000-0003-4305-6306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is intricately linked to gut microbiota dysbiosis and tryptophan (Trp) metabolic dysregulation. This study aimed to clarify the role and mechanisms of 20(S/R)-ginsenoside Rh1 in suppressing colorectal cancer through the regulation of gut microbiota and Trp metabolism. Azoxymethane/dextran sulfate sodium (AOM/DSS)was employed to induce a CRC mouse model, followed by treatment with 20(S/R)-ginsenoside Rh1 at 100 mg·kg

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeGinsenosidesIndoleamine-Pyrrole 2,3,-DioxygenaseReceptors, Aryl HydrocarbonTryptophanAnimalsAzoxymethaneDextran SulfateDysbiosisMaleMiceMice, Inbred C57BLAzoxymethaneDextran Sulfateginsenoside Rh1GinsenosidesIDO1 protein, mouseIndoleamine-Pyrrole 2,3,-DioxygenaseReceptors, Aryl HydrocarbonTryptophan20(S/R)-ginsenoside Rh1anti-tumor immunitycolorectal cancergut microbiotaintestinal barrier protectiontryptophan metabolism

Identifiers

PMID42353193
PMCPMC13299238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.