ArticleInternational journal of molecular sciences2026
Phage-Encoded Depolymerase DepKP144 with Therapeutic Potential Against Both K1- and K2-Type
Ekaterina A Kondakova, Natalia N Golosova, Bogdana I Kravchuk, Yana A Khlusevich, Vyacheslav I Yakubovskij, Yuliya N Kozlova, Svetlana A Grishkova, Nina V Tikunova, Andrey L Matveev
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Ekaterina A KondakovaInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Natalia N GolosovaInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Bogdana I KravchukInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0003-2066-8975 Yana A KhlusevichInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-1413-5876 Vyacheslav I YakubovskijInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Yuliya N KozlovaInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Svetlana A GrishkovaInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Nina V TikunovaInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Andrey L MatveevInstitute of Chemical Biology and Fundamental Medicine Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-6884-6104 Funding
Russian Science Foundation 23-74-10105The Ministry of Education and Science of the Russian Federation 125041005114-8
6 · The paper itselfAbstract
Multidrug resistance (MDR) is a global problem for the healthcare system, complicating the therapy of bacterial infections. It is noted that patients infected with MDR strains often require prolonged hospitalization, have a high risk of mortality, and remain vulnerable to reinfection after recovery. In this study, recombinant phage-encoded depolymerase DepKP144 was produced using the
Indexed as
Anti-Bacterial AgentsBacteriophagesKlebsiella InfectionsKlebsiella pneumoniaeViral ProteinsAnimalsBiofilmsDrug Resistance, Multiple, BacterialHumansMiceAnti-Bacterial AgentsViral Proteinsantibacterialsbiofilm degradationcapsular polysaccharidedepolymeraseK1-typeK2-typeKlebsiella pneumoniaeK. pneumoniaemulti drug resistance
Identifiers
PMID42353184
PMCPMC13300036
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