Evidence map›Paper›PMID 42353159›Full record

ArticleInternational journal of molecular sciences2026

Genetic Determinants of Severe Hypertriglyceridemia: Rare Variants in

Anastasia V Blokhina, Alexey N Meshkov, Alexandra I Ershova, Marija Zaicenoka, Viktoria I Mikhailina, Stepan A Smetnev, Anna A Bukaeva, Alena S Limonova, Anna V Kiseleva, Evgeniia A Sotnikova and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anastasia V BlokhinaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0002-3019-3961
Alexey N MeshkovNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0001-5989-6233
Alexandra I ErshovaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.
Marija ZaicenokaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0002-2798-9811
Viktoria I MikhailinaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0002-5375-7328
Stepan A SmetnevNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0002-8493-4761
Anna A BukaevaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0002-5932-1744
Alena S LimonovaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0003-1500-3696
Anna V KiselevaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0003-4765-8021
Evgeniia A SotnikovaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.
Anastasia A ZharikovaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0003-0723-0493
Elizaveta A NovokhatskayaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0002-9354-3383
Elizaveta V BaranovskayaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0001-9135-1794
Yuri V VyatkinNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.
Vasily E RamenskyNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0001-7867-9509
Maria S PokrovskayaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.
Oxana M DrapkinaNational Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia.ORCID 0000-0003-0323-2635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe hypertriglyceridemia (HTG) is genetically heterogeneous, but its genetic architecture remains incompletely characterized. We investigated the genetic determinants of severe HTG in 123 patients with triglyceride (TG) levels > 5.0 mmol/L and available NGS data. We analyzed rare variants in

Indexed as

HypertriglyceridemiaAdultApolipoprotein A-VApolipoprotein C-IIApolipoproteins EFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenetic VariationGenotypeHumansLipoprotein LipaseMaleMembrane ProteinsMiddle AgedMultifactorial InheritanceAPOA5 protein, humanApoE protein, humanApolipoprotein A-VApolipoprotein C-IIApolipoproteins EGPIHBP1 protein, humanLipoprotein LipaseLMF1 protein, humanLPL protein, humanMembrane ProteinsReceptors, LipoproteinTriglyceridesAPOA5APOC2APOEchylomicronemiafamilial dysbetalipoproteinemiaGPIHBP1LMF1LPLpolygenic risk scoresevere hypertriglyceridemia

Identifiers

PMID42353159
PMCPMC13300099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.