Intracranial Aneurysm-Associated COL22A1 Variants Impair Cerebrovascular Structure and Barrier Integrity in Zebrafish.

Vishal Y Mardhekar, Diandra Rufin Florat, Yatharth Kakkad, Joseph P Broderick, Saulius Sumanas

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vishal Y MardhekarDepartment of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.ORCID 0000-0002-5228-0249

Diandra Rufin FloratDepartment of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.

Yatharth KakkadDepartment of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.

Joseph P BroderickDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-7323-7709

Saulius SumanasDepartment of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA.

Funding

THE ROLE OF COLLAGEN COL22A1 IN INTRACRANIAL ANEURYSMS AND VASCULAR STABILITYR01HL134815 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SUMANAS, SAULIUS · 2017 to 2020

$1.8M

American Heart Association 24PRE1200572NIH HHS R01HL134815

6 · The paper itself

Abstract

Intracranial aneurysms (IAs) represent a major clinical concern due to their risk of rupture and the resulting morbidity and mortality. Both environmental and genetic factors contribute to IA susceptibility, yet the genetic causes of IA remain poorly understood. We previously identified several single nucleotide variants (SNVs) in collagen XXII (

Indexed as

CollagenIntracranial AneurysmPolymorphism, Single NucleotideAnimalsGenetic Predisposition to DiseaseHumansZebrafishCollagenblood–brain barrierCOL22A1intracranial aneurysmvascular stabilityzebrafish

Identifiers

PMID42353150

DOI10.3390/ijms27125434

PMCPMC13300400

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.