ArticleInternational journal of molecular sciences2026
Potential Inhibitory Effect of LED-Sourced Red Light Therapy on Ocular Growth in Normal and Myopic Chicks.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Repeated low-level red light (RLRL) has been reported to control myopia progression clinically. Given safety concerns with laser sources, light-emitting diodes (LED)-sourced red light represents a promising alternative. This study investigated the effects of LED-sourced red light (RL) on cellular response in vitro and ocular growth in normal and lens-induced myopic chicks. In vitro, the mouse photoreceptor 661W cell line was exposed to 625 and 664 nm LED-sourced RL (3 min, twice daily) for 3 days, and cytochrome c oxidase (CCO) activity and cell viability were assessed. In vivo, chicks were randomly assigned to normal visual conditions or monocular -5D lens-induced myopia (LIM). Treatment groups received 664 nm LED-sourced RL (30 min, twice daily) at low, moderate, or high intensities for 10 days. In vitro, LED-sourced RL at 664 nm more effectively activated CCO and enhanced cell viability in 661W cells than RL at 625 nm and white light. In vivo, low-intensity RL exposure of 10 days significantly inhibited vitreous chamber depth (VCD) and axial length (AL) elongation compared to the normal light group (
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