Evidence map›Paper›PMID 42353108›Full record

ArticleInternational journal of molecular sciences2026

Tuning Anticancer Activity and Antimicrobial Response of ZnO Nanoparticles Through Halogenosilane Surface Modification.

Mariana Bușilă, Aurel Tăbăcaru, Andreea Veronica Botezatu, Alina-Mihaela Ceoromila, Ana-Maria Moroșanu, Jeremias Muazeia, Jorge Humberto Gomes Leitão, António Pedro Matos, Fernanda Marques

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariana BușilăDepartment of Manufacturing Engineering, Faculty of Engineering, "Dunărea de Jos" University of Galați, 111 Domnească Street, 800201 Galați, Romania.ORCID 0000-0003-3552-6961
Aurel TăbăcaruDepartment of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunărea de Jos" University of Galați, 111 Domnească Street, 800201 Galați, Romania.ORCID 0000-0001-7677-4473
Andreea Veronica BotezatuDepartment of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunărea de Jos" University of Galați, 111 Domnească Street, 800201 Galați, Romania.ORCID 0000-0003-3194-0102
Alina-Mihaela CeoromilaResearch and Development Center for Thermoset Matrix Composites, Cross-Border Faculty, "Dunărea de Jos" University of Galați, 111 Domneasca Street, 800201 Galați, Romania.ORCID 0000-0002-6734-4911
Ana-Maria MoroșanuInstitute of Biology Bucharest, Romanian Academy, 296 Splaiul Independenței Street, 060031 Bucharest, Romania.ORCID 0000-0001-9383-7296
Jeremias MuazeiaiBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0001-8027-6290
Jorge Humberto Gomes LeitãoiBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0001-8850-274X
António Pedro MatosCentro de Investigação Interdisciplinar Egas Moniz, Campus Universitário Quinta da Granja, Monte Caparica, 2829-511 Caparica, Portugal.
Fernanda MarquesCentro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, Km 139.7, Bobadela, 2695-066 Loures, Portugal.ORCID 0000-0001-8440-5299

Funding

Foundation for Science and Technology UID/04565/2025Instituto Superior Técnico LA/P/0140/2020Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii PN-IV-P2-2.1-TE-2023-1242
6 · The paper itself

Abstract

Surface modification of zinc oxide nanoparticles (ZnO NPs) with organosilane capping agents represents an effective strategy to control their physicochemical and biological properties. In this work, we report for the first time the use of halogenosilanes, namely (3-chloropropyl)trimethoxysilane (CPTMS), (3-bromopropyl)trimethoxysilane (BPTMS) and (3-iodopropyl)trimethoxysilane (IPTMS), for the surface functionalization of ZnO NPs obtained by chemical precipitation. Structural and morphological characterization (PXRD, TEM, SEM-EDX and FTIR) confirmed successful surface modification and revealed a significant particle size reduction from ~31 nm for unmodified ZnO to ~8 nm for BPTMS-modified ZnO (ZnO_b). The biological evaluation showed that halogenosilane-modified ZnO NPs exhibit enhanced cytotoxic activity against prostate cancer cell lines (PC3 and 22Rv1), with ZnO_b displaying the highest activity, likely associated with improved cellular uptake and increased reactive oxygen species (ROS) generation. In contrast, antimicrobial assays revealed only moderate bactericidal effects against

Indexed as

Anti-Infective AgentsAntineoplastic AgentsMetal NanoparticlesNanoparticlesSilanesZinc OxideCell Line, TumorEscherichia coliHumansMicrobial Sensitivity TestsReactive Oxygen SpeciesSurface PropertiesAnti-Infective AgentsAntineoplastic AgentsReactive Oxygen SpeciesSilanesZinc Oxideantimicrobial responseantitumor activityhalogenosilanessurface modificationzinc oxide nanoparticles

Identifiers

PMID42353108
PMCPMC13299290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.