17-DMAG-Loaded HER2-Targeted Extracellular Vesicles Induce PARP/Caspase3-Mediated Apoptosis in Gastric Carcinoma.

Sin Hye Park, Deok Yong Sim, Do Sang Lee, Chan Mi Lee, Joo Won Moon, Ji Won Choi, Dong Jin Kim

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sin Hye ParkDepartment of Gastrointestinal Surgery, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea.ORCID 0000-0002-5095-203X

Deok Yong SimCentral Institute of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0009-0000-6596-7456

Do Sang LeeCentral Institute of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Chan Mi LeeCentral Institute of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Joo Won MoonCentral Institute of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Ji Won ChoiCentral Institute of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Dong Jin KimDepartment of Gastrointestinal Surgery, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea.ORCID 0000-0001-5103-5607

Funding

National Research Foundation of Korea No. 2022R1C1C1011459

6 · The paper itself

Abstract

Gastric cancer remains a major clinical challenge, underscoring the need for more effective drug delivery strategies. Approximately 10-20% of gastric cancers overexpress HER2, conferring aggressive tumor characteristics and poor survival, yet resistance to trastuzumab-based targeted therapy and limited intratumoral antibody penetration continue to restrict clinical outcomes. This study evaluated HER2-targeted exosomes as a delivery platform. Exosomes were engineered to express the p51 peptide, a high-affinity HER2-binding ligand, and loaded with 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a potent HSP90 inhibitor. The cellular uptake and antitumor efficacy of p51-Exo

Indexed as

ApoptosisBenzoquinonesCaspase 3Erb-b2 Receptor Tyrosine KinasesExtracellular VesiclesLactams, MacrocyclicPoly(ADP-ribose) PolymerasesStomach NeoplasmsAnimalsCell Line, TumorCell ProliferationFemaleHumansMiceMice, NudeXenograft Model Antitumor Assays17-(dimethylaminoethylamino)-17-demethoxygeldanamycinBenzoquinonesCaspase 3ERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesLactams, MacrocyclicPoly(ADP-ribose) Polymerases17-DMAGapoptosisexosomesgastric cancerHER2

Identifiers

PMID42353096

DOI10.3390/ijms27125377

PMCPMC13300701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.