Evidence map›Paper›PMID 42353061›Full record

ArticleInternational journal of molecular sciences2026

Treatment of Chronic Liver Fibrosis: Adipose and Bone Marrow Mesenchymal Stem Cells.

Murat Shagidulin, Artem Venediktov, Alexei Grigoriev, Mila Ibragimova, Artur Aktemirov, Aglaya Arzhanova, Pavel Fadeev, Valekh Ashyrov, Viktoria Gartseva, Anastasia Kostysheva and 14 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Murat ShagidulinShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.ORCID 0000-0003-4627-6208
Artem VenediktovDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0000-0002-5604-0461
Alexei GrigorievShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.ORCID 0000-0002-1794-9330
Mila IbragimovaDepartment of Transplantology and Artificial Organs, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0003-0618-017X
Artur AktemirovSoft Matter and Physics of Fluids Center, Bauman Moscow State Technical University, Moscow 105005, Russia.
Aglaya ArzhanovaDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0002-2792-3385
Pavel FadeevDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0009-0385-6385
Valekh AshyrovDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0001-5795-6922
Viktoria GartsevaDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0008-5148-9666
Anastasia KostyshevaDepartment of Transplantology and Artificial Organs, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0001-2718-3949
Ivan LychaginDepartment of Transplantology and Artificial Organs, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0007-8299-7682
Anna PonomarevaShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.
Lidia SalomatinaShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.
Alina VaniukovaDepartment of Transplantology and Artificial Organs, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
Alla NikolskayaShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.ORCID 0000-0001-7410-6500
Sergei PershikovDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0000-0003-4764-4017
Egor KuzminDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0000-0003-4098-1125
Ksenia PokidovaDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0009-0000-0323-7669
Nikolai ZharovDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
Natalia KartashkinaDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
Yulia BasokShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.ORCID 0000-0003-4807-3164
Nina OnishchenkoShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.ORCID 0000-0002-0889-8674
Gennadii PiavchenkoDepartment of Human Anatomy and Histology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.ORCID 0000-0001-7782-3468
Sergei GautierShumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow 123182, Russia.ORCID 0000-0003-0633-678X

Funding

Ministry of Science and Higher Education of the Russian Federation Agreement No. 075-15-2025-669 from August 5, 2025
6 · The paper itself

Abstract

Liver fibrosis is a severe but common disease without an easy-to-access option for efficient treatment. Mesenchymal stem cells (MSCs) of different origins have been tested for antifibrotic effects in vitro, in vivo, and in clinical studies over the two last decades, although the comparative efficiency of different subtypes remains not fully understood, especially for long-term survival. In this study, we aimed to compare the long-time persistence of favorable effects in male Wistar rats with liver fibrosis treated using MSCs derived from white adipose tissue (AdMSCs) and bone marrow (BMSCs). Liver fibrosis was induced by carbon tetrachloride. We studied the survival rate; oxidative index, assessed via laser Doppler flowmetry; hepatic markers in blood plasma-albumin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase; the ratio of liver to body mass; histological parameters-the number of adipocytes, lymphocytes, siderophages, and Ki67

Indexed as

Adipose Tissue, WhiteBone Marrow CellsLiver CirrhosisMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAdipose TissueAnimalsCarbon TetrachlorideLiverMaleRatsRats, WistarCarbon TetrachlorideAdMSCsBMSCscomparative studyliver regenerationMSCnichetissue homeostasis

Identifiers

PMID42353061
PMCPMC13299298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.