Evidence map›Paper›PMID 42353057›Full record

ArticleInternational journal of molecular sciences2026

Autophagy Is Suppressed in Peripheral Blood Mononuclear Cells During Chronic Obstructive Pulmonary Disease.

James M Cooper, Shiye Chen, Susan E Lester, Julia Kim, Jason Gummow, Thomas Crowhurst, Emily Lawton, Arash Badiei, Phan T Nguyen, Paul N Reynolds and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

James M CooperAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0002-8919-5865
Shiye ChenAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0009-0009-6669-9639
Susan E LesterAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Julia KimDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Jason GummowAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Thomas CrowhurstAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0003-4873-5439
Emily LawtonAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0002-6785-5797
Arash BadieiAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Phan T NguyenAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Paul N ReynoldsAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Hubertus P A JersmannAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
Eugene RoscioliAdelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0002-3201-3899

Funding

Health Services Charitable Gifts Board 25-16Rebecca L. Cooper Medical Research Foundation 12630Royal Adelaide Hospital 15854
6 · The paper itself

Abstract

Assessing autophagy may offer insights into the pathogenesis of chronic obstructive pulmonary disease (COPD). However, measuring the dynamic aspect of autophagy is challenging, and sample manipulation can cause signal fluctuations that deviate from physiological conditions. We applied an organotypic method to quantify autophagy in COPD, where it frequently demonstrates disease-related dysregulation. Blood from control and COPD participants was treated with or without chloroquine. Microtubule-associated protein 1 light chain 3B II (LC3B-II) abundance was quantified in peripheral blood mononuclear cells (PBMCs), and findings were validated by transmission electron microscopy. Our observations show that while basal LC3B-II abundance was similar between groups (

Indexed as

AutophagyLeukocytes, MononuclearPulmonary Disease, Chronic ObstructiveAgedChloroquineFemaleHumansMaleMicrotubule-Associated ProteinsMiddle AgedChloroquineMAP1LC3B protein, humanMicrotubule-Associated Proteinsairwayautophagybiochemistrychronic obstructive pulmonary diseasediagnosticLC3lymphocyterespiratory

Identifiers

PMID42353057
PMCPMC13299432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.