Evidence map›Paper›PMID 42353009›Full record

ArticleInternational journal of molecular sciences2026

Withanolides Are Detected in Human Urine Following Oral Administration of a

Alex B Speers, Ellala D Limoico, Axel Lozano-Ortiz, Luke Marney, Jaewoo Choi, Sarah A Barr, R Thomas Williamson, Wendy K Strangman, Claudia S Maier, Amala Soumyanath

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alex B SpeersBENFRA (Botanicals Enhancing Neurological and Functional Resilience in Aging) Botanical Dietary Supplements Research Center, Oregon Health & Science University (OHSU), Portland, OR 97239, USA.ORCID 0000-0001-5580-3298
Ellala D LimoicoBENFRA (Botanicals Enhancing Neurological and Functional Resilience in Aging) Botanical Dietary Supplements Research Center, Oregon Health & Science University (OHSU), Portland, OR 97239, USA.
Axel Lozano-OrtizBENFRA (Botanicals Enhancing Neurological and Functional Resilience in Aging) Botanical Dietary Supplements Research Center, Oregon Health & Science University (OHSU), Portland, OR 97239, USA.
Luke MarneyBENFRA (Botanicals Enhancing Neurological and Functional Resilience in Aging) Botanical Dietary Supplements Research Center, Oregon Health & Science University (OHSU), Portland, OR 97239, USA.ORCID 0000-0001-8117-8246
Jaewoo ChoiBENFRA (Botanicals Enhancing Neurological and Functional Resilience in Aging) Botanical Dietary Supplements Research Center, Oregon Health & Science University (OHSU), Portland, OR 97239, USA.ORCID 0000-0001-6376-3089
Sarah A BarrDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
R Thomas WilliamsonDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Wendy K StrangmanDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA.ORCID 0000-0002-6911-4909
Claudia S MaierBENFRA (Botanicals Enhancing Neurological and Functional Resilience in Aging) Botanical Dietary Supplements Research Center, Oregon Health & Science University (OHSU), Portland, OR 97239, USA.
Amala SoumyanathBENFRA (Botanicals Enhancing Neurological and Functional Resilience in Aging) Botanical Dietary Supplements Research Center, Oregon Health & Science University (OHSU), Portland, OR 97239, USA.ORCID 0000-0003-1569-6453

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Joel Summer Steele · 2020 to 2026
$28.6M
Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
Mechanisms underlying the cognitive effects of Centella asiatica water extract and constituent compounds in the 5xFAD mouse model of Alzheimer's DiseaseU19AT010829 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAIER, CLAUDIA S · 2020 to 2024
$6.1M
U-RISE at Portland State UniversityT34GM141989 · NIGMS · PORTLAND STATE UNIVERSITY · PI KELLER, THOMAS E, MORRIS, CYNTHIA D · 2021 to 2025
$2.5M
NCATS NIH HHS KL2TR002370NCCIH NIH HHS U19AT010829NIA NIH HHS P30AG066518NIGMS NIH HHS T34GM141989ODCDC CDC HHS S10OD026922Office of Dietary Supplements R03AT012460
6 · The paper itself

Abstract

Ashwagandha (

Indexed as

Plant ExtractsWithaniaWithanolidesAdministration, OralAgedFemaleHumansMaleAshwagandhaPlant Extractswithaferin AWithanolidesashwagandhaliquid chromatographymass spectrometrypharmacokineticsurinewithaferin AWithania somniferawithanolides

Identifiers

PMID42353009
PMCPMC13299707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.