A Multi-Level miRNA Regulatory Network Associated with IRF1 Expression in Non-Small Cell Lung Cancer: In Silico Identification of Candidate Biomarkers for Immunotherapy Response.

Dariya V Karaseva, Alina M Perevalova, Tatiana S Kalinina, Vladislav V Kononchuk, Vadim V Kozlov, Lyudmila F Gulyaeva, Vladimir O Pustylnyak

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dariya V KarasevaInstitute for the Medicine and Medical Technology, Novosibirsk State University, Pirogova Street, 1, 630090 Novosibirsk, Russia.

Alina M PerevalovaInstitute for the Medicine and Medical Technology, Novosibirsk State University, Pirogova Street, 1, 630090 Novosibirsk, Russia.ORCID 0009-0004-0139-5726

Tatiana S KalininaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Street, 2/12, 630117 Novosibirsk, Russia.ORCID 0000-0002-2698-0866

Vladislav V KononchukInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Street, 2/12, 630117 Novosibirsk, Russia.

Vadim V KozlovInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Street, 2/12, 630117 Novosibirsk, Russia.

Lyudmila F GulyaevaInstitute for the Medicine and Medical Technology, Novosibirsk State University, Pirogova Street, 1, 630090 Novosibirsk, Russia.ORCID 0000-0002-7693-3777

Vladimir O PustylnyakInstitute for the Medicine and Medical Technology, Novosibirsk State University, Pirogova Street, 1, 630090 Novosibirsk, Russia.ORCID 0000-0003-0547-5534

Funding

Russian Science Foundation 25‑25‑00647

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). However, the limited predictive value of PD-L1 expression as a biomarker underscores the urgent need for more reliable predictors of ICI response. Interferon regulatory factor 1 (IRF1) is a transcription factor that lies downstream of interferon-γ signaling and directly regulates

Indexed as

Biomarkers, TumorCarcinoma, Non-Small-Cell LungGene Expression Regulation, NeoplasticGene Regulatory NetworksInterferon Regulatory Factor-1Lung NeoplasmsMicroRNAs3' Untranslated RegionsB7-H1 AntigenComputational BiologyComputer SimulationHumansImmunotherapy3' Untranslated RegionsB7-H1 AntigenBiomarkers, TumorCD274 protein, humanInterferon Regulatory Factor-1IRF1 protein, humanMicroRNAsbiomarkerimmune checkpoint inhibitorsIRF1microRNAmiR-141miR-183miR-301bNFKB1non-small cell lung cancerPD-L1STAT4

Identifiers

PMID42352916

DOI10.3390/ijms27125192

PMCPMC13300628

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.