ArticleBrain sciences2026
Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice.
Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Chromosomal and gonadal sex have differing effects on social motivation in mice.Biology of sex differences · 2025Article
- Chromosomal and gonadal sex have differing effects on social motivation in mice.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in susceptibility to substance use disorder: Role for X chromosome inactivation and escape?Molecular and cellular neurosciences · 2023Review
- Sex chromosome and gonadal hormone contributions to binge-like and aversion-resistant ethanol drinking behaviors in Four Core Genotypes mice.Frontiers in psychiatry · 2023Article
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3 authors.
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Abstract
BACKGROUND/
objectivesSex differences in ethanol consumption have been reported in both humans and laboratory rodents, but the independent/dependent contributions of genetic and hormonal sex biasing mechanisms to these phenotypes have not yet been fully explored.
methodsTo examine the contributions of sex-chromosome complement (SCC) and gonadal sex (GS) to ethanol consumption, we studied adolescent (28-32 days old) four core genotypes (FCG) mice on a C57BL/6J background, a model which allows for independent assortment of GS and SCC. A modified drinking-in-the-dark (DID) procedure was employed, in which mice were offered concurrent access to 20%, 10% and 0% ethanol (in water) in four daily 2 h sessions. Consumption at the level of individual bouts was recorded.
resultsOverall ethanol intake differed substantially by group and was driven almost entirely by differences in consumption of the 20% ethanol solution; all groups preferred the 20% solution over the 10% and 0% solutions, but consumed similar amounts of the 10% and 0% solutions. Intake of the 20% ethanol solution followed the rank order XXM > XYM > XYF > XXF. This pattern reflects an interaction between SCC and GS, such that SCC effects were greatest in gonadal females (XY > XX), whereas GS effects were greatest in XX mice (gonadal males > gonadal females). Moreover, the magnitude of these effects varied both across and within drinking sessions. The behavioral microstructure of ethanol consumption (i.e., parameterization of within-session discriminable drinking bouts) support the validity of our three-bottle modification of the DID procedure as a model of binge-like consumption, because (1) the consumption rate of the 20% ethanol solution was ~80 g EtOH/kg/h within a bout (~12 s/bout, ~three bouts/session), (2) most of this ethanol consumption was completed in a single bout and (3) within-session ethanol consumption was greater earlier than later, indicating "front loading."
conclusionsThese results suggest that the effects of GS on binge-like ethanol consumption are observed in early adolescence and moderated by SCC in adolescent FCG mice, with GS effects most pronounced in XX mice and SCC effects evident mainly in gonadal females.
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