Evidence map›Paper›PMID 42352486›Full record

ReviewCancers2026

Personalized Treatment of Head and Neck Cancers: Role of Functional Imaging and AI.

Joran Tanghe, Rüveyda Dok, Sandra Nuyts

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joran TangheLaboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.ORCID 0009-0000-9727-1568
Rüveyda DokLaboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-5456-814X
Sandra NuytsLaboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-5540-4796

Funding

Kom op tegen Kanker 13142Research Foundation - Flanders 18B4122N
6 · The paper itself

Abstract

Chemoradiotherapy plays an important role in the management of locally advanced head and neck squamous cell carcinoma. Unfortunately, a substantial fraction of patients experience treatment failure, while others suffer from significant treatment-related toxicity caused by intensive chemoradiotherapy regimens. This underscores the need for new biomarkers that can accurately capture the biological tumor heterogeneity and guide personalized therapy. Functional imaging combined with AI-based approaches such as radiomics and deep learning may offer a promising strategy for treatment stratification. However, a substantial number of challenges remain before clinical implementation can be achieved. Therefore, this review proposes a biology-driven framework for AI analysis of functional imaging in head and neck squamous cell carcinoma. In addition, it emphasizes the need for clinically oriented validation strategies to facilitate the translation of stratification models into clinical management.

Indexed as

chemoradiotherapydeep learninghead and neck squamous cell carcinomamagnetic resonance imagingpositron emission tomographyradiomicsreview

Identifiers

PMID42352486
PMCPMC13297241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.