ArticleCancers2026
The Heterogeneity of Mucinous Colorectal Adenocarcinoma-Histologic and Molecular Phenotypes Drive Prognostic Outcomes.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
BACKGROUND/
objectivesThe prognostic significance of mucinous colorectal adenocarcinoma (MAC) is controversial. Some studies report good outcomes relative to conventional colorectal adenocarcinoma (CRC) as is similarly described for MACs in, e.g., the breast, lung, pancreas and prostate. However, other studies refute this, proclaiming either no difference or worse outcomes. Herein, we proffer additional insights into the biology of MAC to explain these conflicting findings.
methodsA literature search was undertaken using keywords pertaining to MAC. Archival cases from our database were analyzed to provide context for our findings. MAIN
findingsThe unifying histologic feature of MACs is their >50% content of extracellular mucin, but they should not be viewed as a monolithic entity, as is commonly portrayed in databases. Instead, MAC is a heterogenous disease as defined by histologic and molecular phenotypes. For example, MACs arising from adenoma-like CRC have relatively good outcomes unlike those from traditional serrated adenomas. Likewise, other factors such as histologic grade (grade 1-3), genomics (e.g.,
conclusionsIn contrast to previous studies that largely demarcated MAC as a discrete entity, this paper shows the limitations of this approach by highlighting the various sub-entities comprising MAC. Recognition of this heterogeneity may help to inform future treatment algorithms.
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