Oxidative Stress and Necrotizing Enterocolitis in Preterm Newborns: The Role of GSTM1 and GSTT1 Null Genotypes.

Alexandre Alberto Barros Duarte, Danielle Lopes Teixeira Ferdinando, Vânia Belintani Piatto, Heloísa Cristina Caldas

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Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Alexandre Alberto Barros DuarteDepartamento de Pediatria e Cirurgia Pediátrica, Faculdade de Medicina de São José do Rio Preto (FAMERP), Hospital da Criança e Maternidade (FUNFARME), Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, São Paulo CEP-15090-000, Brazil.

Danielle Lopes Teixeira FerdinandoDepartamento de Pediatria e Cirurgia Pediátrica, Faculdade de Medicina de São José do Rio Preto (FAMERP), Hospital da Criança e Maternidade (FUNFARME), Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, São Paulo CEP-15090-000, Brazil.ORCID 0009-0001-0644-728X

Vânia Belintani PiattoDepartamento de Anatomia, Faculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, São José of Rio Preto, São Paulo CEP-15090-000, Brazil.ORCID 0000-0003-2677-8243

Heloísa Cristina CaldasDepartamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto (FAMERP), Hospital da Criança e Maternidade (FUNFARME), Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, São Paulo CEP-15090-000, Brazil.ORCID 0000-0002-8303-3929

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a multifactorial disease associated with prematurity, intestinal hypoperfusion, dysbiosis, and oxidative stress. Interindividual variability in disease occurrence suggests a role for genetic susceptibility. Null genotypes of the GSTM1 and GSTT1 genes result in absent glutathione S-transferase activity and may impair antioxidant defenses. This study investigated whether GSTM1 and GSTT1 null genotypes are associated with NEC development and severity in preterm newborns. This single-center case-control pilot study included 100 preterm newborns (50 NEC and 50 controls). Genotyping was performed by multiplex polymerase chain reaction. Baseline characteristics were comparable between groups (

Indexed as

Enterocolitis, NecrotizingGlutathione TransferaseOxidative StressCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansInfant, NewbornInfant, PrematureMalePilot Projectsglutathione S-transferase T1Glutathione Transferaseglutathione transferasenecrotizing enterocolitisoxidative stresspreterm infants

Identifiers

PMID42352369

DOI10.3390/biom16060900

PMCPMC13297310

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.