Evidence map›Paper›PMID 42352285›Full record

ArticleBiomolecules2026

Zeaxanthin Modulates Early Metabolic and Inflammatory Responses in db/db Mice: Associations with Intestinal Lipid Handling and Gut Microbiome Remodeling.

Yashu Tang, Peiran Lu, Huimin Chen, Siauyen Wong, Md Salahuddin, Mehedi Hasan, Sanmi E Alake, Yoo Kim, McKale Montgomery, Winyoo Chowanadisai and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yashu TangDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Peiran LuDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0009-0001-5096-3046
Huimin ChenDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0009-0001-9291-7283
Siauyen WongDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Md SalahuddinDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0003-0268-1084
Mehedi HasanDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Sanmi E AlakeDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-9383-229X
Yoo KimDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-4525-1319
McKale MontgomeryDepartment of Nutritional Sciences, Texas Christian University, Fort Worth, TX 76109, USA.ORCID 0000-0001-5318-6687
Winyoo ChowanadisaiDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Brenda J SmithDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-7296-8534
Stephen L ClarkeDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Edralin A LucasDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-4983-1193
Chwan-Li ShenDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79409, USA.ORCID 0000-0001-9595-6598
Minghua TangDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0009-0003-7645-8069
Dingbo LinDepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-7441-8210

Funding

National Institute of Food and Agriculture 2020-67017-30842National Institute of Food and Agriculture 2021-67018-34023
6 · The paper itself

Abstract

Dietary zeaxanthin exhibits low intestinal absorption efficiency, and circulating levels are reduced in individuals with type 2 diabetes, suggesting potential metabolic relevance. However, its role during early-stage diabetes remains incompletely understood. This study examined whether dietary zeaxanthin modulates early metabolic and inflammatory responses and influences host-microbiome interactions during early T2DM progression. Four-week-old male db/db mice and wild-type C57BL/6J mice were fed an AIN-93M diet with or without 0.02% (

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Gastrointestinal MicrobiomeInflammationLipid MetabolismZeaxanthinsAnimalsBlood GlucoseLiverMaleMiceMice, Inbred C57BLBlood GlucoseZeaxanthinsadipositygut microbiomeinflammatory signalingintestinal lipid transporttype 2 diabeteszeaxanthin

Identifiers

PMID42352285
PMCPMC13296385

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.