SynthesisBiomolecules2026
Effects of Physical Exercise with and Without Nutritional Supplementation on Serum Albumin in Older People: A Systematic Review and Meta-Analysis.
Synthesis in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis comprehensive review with meta-analysis was to evaluate the effects of physical exercise interventions alone, as well as in combination with nutritional supplementation, on serum albumin levels in older people.
methodsA systematic literature review was performed across eight general electronic databases from inception to March 2026. The risk of bias was evaluated with the RoB 2 tool, and the certainty of evidence was determined using GRADE. The protocol has been registered in PROSPERO with registration number CRD420251072030.
resultsA total of six randomized controlled trials were included, involving 330 older people (mean age: 72.1 ± 5.4 years, 61% female). Physical exercise interventions alone significantly improved serum albumin levels in older people, whereas combined interventions including nutritional supplementation did not show additional significant effects. The majority of the studies assessed were deemed to have a significant risk of bias, resulting in a low overall certainty of evidence.
conclusionsPhysical exercise treatments elevated blood albumin levels in older people; however, the combination of physical exercise and nutritional supplementation did not have a meaningful effect. Due to the limited reliability of the evidence, more extensive, high-caliber research are required.
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